ArticleNature communications2013
Magnetic barcode assay for genetic detection of pathogens.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Nanoparticles as an Alternative Strategy for the Rapid Detection ofIET nanobiotechnology · 2025Pooled it
- Current progress of functional nanobiosensors for potential tuberculosis diagnosis: The novel way for TB control?Frontiers in bioengineering and biotechnology · 2022Pooled it
- Microfluidics-Based Nanobiosensors for Healthcare Monitoring.Molecular biotechnology · 2024Review
- Review
- Rapid and Live-Cell Detection of Senescence in Mesenchymal Stem Cells by Micro Magnetic Resonance Relaxometry.Stem cells translational medicine · 2023Article
- An Insight into Advances in Developing Nanotechnology Based Therapeutics, Drug Delivery, Diagnostics and Vaccines: Multidimensional Applications in Tuberculosis Disease Management.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Microfluidics-based strategies for molecular diagnostics of infectious diseases.Military Medical Research · 2022Review
- A portable NMR platform with arbitrary phase control and temperature compensation.Magnetic resonance (Gottingen, Germany) · 2022Article
- Development of Integrated Systems for On-Site Infection Detection.Accounts of chemical research · 2021Review
- Aspects of Point-of-Care Diagnostics for Personalized Health Wellness.International journal of nanomedicine · 2021Review
- A Microfluidic Chip-Based MRS Immunosensor for Biomarker DetectionFrontiers in chemistry · 2021Article
- Creation of Curved Nanostructures Using Soft-Materials-Derived Lithography.Nanomaterials (Basel, Switzerland) · 2020Article
- Machine learning assistive rapid, label-free molecular phenotyping of blood with two-dimensional NMR correlational spectroscopy.Communications biology · 2020Article
- Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system.NPJ aging and mechanisms of disease · 2020Article
- Omics Meeting Onics: Towards the Next Generation of Spectroscopic-Based Technologies in Personalized Medicine.Journal of personalized medicine · 2019Article
- Novel diagnostics for point-of-care bacterial detection and identification.RSC advances · 2019Review
- Current Trends of Nanobiosensors for Point-of-Care Diagnostics.Journal of analytical methods in chemistry · 2019Review
- Diagnosis of traumatic brain injury using miRNA signatures in nanomagnetically isolated brain-derived extracellular vesicles.Lab on a chip · 2018Article
- Precise supramolecular control of surface coverage densities on polymer micro- and nanoparticles.Chemical science · 2018Article
- Point-of-care microfluidic devices for pathogen detection.Biosensors & bioelectronics · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
The task of rapidly identifying patients infected with Mycobacterium tuberculosis in resource-constrained environments remains a challenge. A sensitive and robust platform that does not require bacterial isolation or culture is critical in making informed diagnostic and therapeutic decisions. Here we introduce a platform for the detection of nucleic acids based on a magnetic barcoding strategy. PCR-amplified mycobacterial genes are sequence-specifically captured on microspheres, labelled by magnetic nanoprobes and detected by nuclear magnetic resonance. All components are integrated into a single, small fluidic cartridge for streamlined on-chip operation. We use this platform to detect M. tuberculosis and identify drug-resistance strains from mechanically processed sputum samples within 2.5 h. The specificity of the assay is confirmed by detecting a panel of clinically relevant non-M. tuberculosis bacteria, and the clinical utility is demonstrated by the measurements in M. tuberculosis-positive patient specimens. Combined with portable systems, the magnetic barcode assay holds promise to become a sensitive, high-throughput and low-cost platform for point-of-care diagnostics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.