ArticleNature communications2013
Competing signals drive telencephalon diversity.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Genome-Wide Evolution of Lineage-Specific Chromatin Accessibility Links Regulatory Changes to Cichlid Phenotypic Diversity.Genome biology and evolution · 2026Article
- Ocean acidification induces neuronal hyperexcitation and anxiety-like behaviour in marine medaka via ASIC activation.Fish physiology and biochemistry · 2026Article
- East African cichlid fishes.EvoDevo · 2023Review
- Teleost Fish and Organoids: Alternative Windows Into the Development of Healthy and Diseased Brains.Frontiers in molecular neuroscience · 2022Review
- Evolution of regulatory networks associated with traits under selection in cichlids.Genome biology · 2021Article
- Analysis of structural variants in four African cichlids highlights an association with developmental and immune related genes.BMC evolutionary biology · 2020Article
- Using Teleost Fish to Discern Developmental Signatures of Evolutionary Adaptation From Phenotypic Plasticity in Brain Structure.Frontiers in neuroanatomy · 2020Article
- Behavioral evolution contributes to hindbrain diversification among Lake Malawi cichlid fish.Scientific reports · 2019Article
- Evolutionary diversity as a catalyst for biological discovery.Integrative zoology · 2018Review
- Developmental evolution of the forebrain in cavefish, from natural variations in neuropeptides to behavior.eLife · 2018Article
- Applying gene regulatory network logic to the evolution of social behavior.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- A compendium of developmental gene expression in Lake Malawi cichlid fishes.BMC developmental biology · 2017Article
- Six3 dosage mediates the pathogenesis of holoprosencephaly.Development (Cambridge, England) · 2016Article
- Cichlid fishes as a model to understand normal and clinical craniofacial variation.Developmental biology · 2016Article
- Article
- Wnt signalling underlies the evolution of new phenotypes and craniofacial variability in Lake Malawi cichlids.Nature communications · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The telencephalon is the most complex brain region, controlling communication, emotion, movement and memory. Its adult derivatives develop from the dorsal pallium and ventral subpallium. Despite knowledge of genes required in these territories, we do not understand how evolution has shaped telencephalon diversity. Here, using rock- and sand-dwelling cichlid fishes from Lake Malawi, we demonstrate that differences in strength and timing of opposing Hedgehog and Wingless signals establish evolutionary divergence in dorsal-ventral telencephalon patterning. Rock dwellers exhibit early, extensive Hedgehog activity in the ventral forebrain resulting in expression of foxg1 before dorsal Wingless signals, and a larger subpallium. Sand dwellers show rapid deployment of Wingless, later foxg1 expression and a larger pallium. Manipulation of the Hedgehog and Wingless pathways in cichlid and zebrafish embryos is sufficient to mimic differences between rock- versus sand-dweller brains. Our data suggest that competing ventral Hedgehog and dorsal Wingless signals mediate evolutionary diversification of the telencephalon.
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Registered trials
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