ArticleNature communications2013
Basophils are required for the induction of Th2 immunity to haptens and peptide antigens.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Systems analysis of immune responses to attenuated P. falciparum malaria sporozoite vaccination reveals excessive inflammatory signatures correlating with impaired immunity.PLoS pathogens · 2022Trial
- Basophils in atopic dermatitis: Immunologic roles and clinical implications.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Review
- Thymic stromal lymphopoietin-activated basophil promotes lung inflammation in mouse atopic march model.Frontiers in immunology · 2025Article
- Basophils are important for development of allergic skin inflammation.The Journal of allergy and clinical immunology · 2024Article
- PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus.Nature communications · 2024Article
- Editorial: The fundamental biology of basophils in health and disease.Frontiers in immunology · 2023Article
- Balamuthia mandrillaris trophozoites ingest human neuronal cells via a trogocytosis-independent mechanism.Parasites & vectors · 2022Article
- Basophils control T cell priming through soluble mediators rather than antigen presentation.Frontiers in immunology · 2022Review
- Bidirectional associations between eosinophils, basophils, and lymphocytes with atopic dermatitis: A multivariable Mendelian randomization study.Frontiers in immunology · 2022Article
- Role of Basophils in a Broad Spectrum of Disorders.Frontiers in immunology · 2022Review
- Review
- IL-37 Targets TSLP-Primed Basophils to Alleviate Atopic Dermatitis.International journal of molecular sciences · 2021Article
- Review
- IgE Autoreactivity in Atopic Dermatitis: Paving the Road for Autoimmune Diseases?Antibodies (Basel, Switzerland) · 2020Review
- Increased number and activation of peripheral basophils in adult-onset minimal change disease.Journal of cellular and molecular medicine · 2020Article
- Allergenicity of Deamidated and/or Peptide-Bond-Hydrolyzed Wheat Gliadin by Transdermal Administration.Foods (Basel, Switzerland) · 2020Article
- Basophils and Eosinophils in Nematode Infections.Frontiers in immunology · 2020Review
- New insights into roles of basophils in initiating T helper type 2 immunity.Chinese herbal medicines · 2020Article
- The Gastrointestinal HelminthFrontiers in immunology · 2020Article
- Core Concept: Cells nibble one another via the under-appreciated process of trogocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2019Review
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relative contributions of basophils and dendritic cells in Th2 skewing to foreign antigen exposure remain unclear. Here we report the ability of basophils to induce Th2 polarization upon epicutaneous sensitization with different antigens using basophil conditionally depleted Bas TRECK transgenic mice. Basophils are responsible for Th2 skewing to haptens and peptide antigens, but not protein antigens in vivo. Consistent with this, basophils cannot take up or process ovalbumin protein in significant quantities, but present ovalbumin peptide to T cells for Th2 differentiation via major histocompatibility complex class II. Intriguingly, basophils promote Th2 skewing upon ovalbumin protein exposure in the presence of dendritic cells. Taken together, our results suggest that basophils alone are able to induce Th2 skewing with haptens and peptide antigens but require dendritic cells for the induction of Th2 for protein antigens upon epicutaneous immunization.
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