ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2013
In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed.
- Article
- Fluid transport in the brain.Physiological reviews · 2022Review
- Reversible Ratiometric NADH Sensing Using Semiconducting Polymer Dots.Angewandte Chemie (International ed. in English) · 2021Article
- Cerebrospinal fluid influx drives acute ischemic tissue swelling.Science (New York, N.Y.) · 2020Article
- Gamabufotalin induces a negative feedback loop connecting ATP1A3 expression and the AQP4 pathway to promote temozolomide sensitivity in glioblastoma cells by targeting the amino acid Thr794.Cell proliferation · 2020Article
- Evaluating Cell Metabolism Through Autofluorescence Imaging of NAD(P)H and FAD.Antioxidants & redox signaling · 2019Review
- Increased cerebral vascularization and decreased water exchange across the blood-brain barrier in aquaporin-4 knockout mice.PloS one · 2019Article
- Dissociation between CSD-Evoked Metabolic Perturbations and Meningeal Afferent Activation and Sensitization: Implications for Mechanisms of Migraine Headache Onset.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The potential roles of aquaporin 4 in malignant gliomas.Oncotarget · 2017Review
- Dynamic diameter response of intraparenchymal penetrating arteries during cortical spreading depression and elimination of vasoreactivity to hypercapnia in anesthetized mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Deletion of Aquaporin-4 Curtails Extracellular Glutamate Elevation in Cortical Spreading Depression in Awake Mice.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Brain edema: a valid endpoint for measuring hepatic encephalopathy?Metabolic brain disease · 2016Review
- The Potential Roles of Aquaporin 4 in Alzheimer's Disease.Molecular neurobiology · 2016Review
- The Neuroprotective Effect of the Association of Aquaporin-4/Glutamate Transporter-1 against Alzheimer's Disease.Neural plasticity · 2016Review
- Aquaporin-4 regulates the velocity and frequency of cortical spreading depression in mice.Glia · 2015Article
- Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature.Physiological reviews · 2015Review
- Deletion of aquaporin-4 increases extracellular K(+) concentration during synaptic stimulation in mouse hippocampus.Brain structure & function · 2015Article
- Hyperperfusion counteracted by transient rapid vasoconstriction followed by long-lasting oligemia induced by cortical spreading depression in anesthetized mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- The inner CSF-brain barrier: developmentally controlled access to the brain via intercellular junctions.Frontiers in neuroscience · 2015Article
- Physiological roles of aquaporin-4 in brain.Physiological reviews · 2013Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Using in vivo two-photon imaging, we show that mice deficient in aquaporin-4 (AQP4) display increased fluorescence of nicotinamide adenine dinucleotide (NADH) when subjected to cortical spreading depression. The increased NADH signal, a proxy of tissue hypoxia, was restricted to microwatershed areas remote from the vasculature. Aqp4 deletion had no effects on the hyperemia response, but slowed [K(+)]o recovery. These observations suggest that K(+) uptake is suppressed in Aqp4(-/-) mice as a consequence of decreased oxygen delivery to tissue located furthest away from the vascular source of oxygen, although increased oxygen consumption may also contribute to our observations.
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