ReviewSeminars in pediatric surgery2013
The role of the intestinal microbiota in the pathogenesis of necrotizing enterocolitis.
Review in Seminars in pediatric surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis.Microbiome · 2017Pooled it
- Article
- Impact of Delayed Time to Antibiotics in Medical and Surgical Necrotizing Enterocolitis.Children (Basel, Switzerland) · 2023Article
- Use of sildenafil and L-arginine in an experimental rat model for the prevention of neonatal necrotizing enterocolitis.Scientific reports · 2022Article
- Understanding the development and function of the gut microbiota in health and inflammation.Frontline gastroenterology · 2022Article
- Necrotizing Enterocolitis in Children with Congenital Heart Disease: A Literature Review.Pediatric cardiology · 2021Review
- Fatty acid metabolism and acyl-CoA synthetases in theWorld journal of hepatology · 2021Review
- Review
- Review
- Urine NMR Metabolomics Profile of Preterm Infants With Necrotizing Enterocolitis Over the First Two Months of Life: A Pilot Longitudinal Case-Control Study.Frontiers in molecular biosciences · 2021Article
- Survey on antibiotic regimens for necrotizing enterocolitis prescribed by Chinese pediatricians in 2020.World journal of pediatric surgery · 2021Article
- Changes of intestinal microflora in neonatal necrotizing enterocolitis: a single-center study.The Journal of international medical research · 2020Article
- Perivascular localization of macrophages in the intestinal mucosa is regulated by Nr4a1 and the microbiome.Nature communications · 2020Article
- Autoinducer-2 May Be a New Biomarker for Monitoring Neonatal Necrotizing Enterocolitis.Frontiers in cellular and infection microbiology · 2020Article
- Pro-inflammatory agents released by pathogens, dying host cells, and neutrophils act synergistically to destroy host tissues: a working hypothesis.Journal of inflammation research · 2019Review
- Effects of artificially introduced Enterococcus faecalis strains in experimental necrotizing enterocolitis.PloS one · 2019Article
- Gut and Lung Microbiota in Preterm Infants: Immunological Modulation and Implication in Neonatal Outcomes.Frontiers in immunology · 2019Review
- An enhanced Lactobacillus reuteri biofilm formulation that increases protection against experimental necrotizing enterocolitis.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- The Roles of Two Type VI Secretion Systems inFrontiers in microbiology · 2018Article
- Colonization with Escherichia coli EC 25 protects neonatal rats from necrotizing enterocolitis.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Development of necrotizing enterocolitis (NEC) requires a susceptible host, typically a premature infant or an infant with congenital heart disease, enteral feedings and bacterial colonization. Although there is little doubt that microbes are critically involved in the pathogenesis of NEC, the identity of specific causative pathogens remains elusive. Unlike established normal adult gut microbiota, which is quite complex, uniform, and stable, early postnatal bacterial populations are simple, diverse, and fluid. These properties complicate studies aimed at elucidating characteristics of the gut microbiome that may play a role in the pathogenesis of NEC. A broad variety of bacterial, viral, and fungal species have been implicated in both clinical and experimental NEC. Frequently, however, the same species have also been found in physiologically matched healthy individuals. Clustered outbreaks of NEC, in which the same strain of a suspected pathogen is detected in several patients suggest, but do not prove, a causative relationship between the specific pathogen and the disease. Studies in Cronobacter sakazakii, the best characterized NEC pathogen, have demonstrated that virulence is not a property of a bacterial species as a whole, but rather a characteristic of certain strains, which may explain why the same species can be pathogenic or non-pathogenic. The fact that a given microbe may be innocuous in a full-term, yet pathogenic in a pre-term infant has led to the idea of opportunistic pathogens in NEC. Progress in understanding the infectious nature of NEC may require identifying specific pathogenic strains and unambiguously establishing their virulence in animal models.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.