ArticleCNS neuroscience & therapeutics2013
Oxidative stress is not involved in motion sickness in mice.
Article in CNS neuroscience & therapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- The Combination of Scopolamine and Psychostimulants for the Prevention of Severe Motion Sickness.CNS neuroscience & therapeutics · 2016Article
- Subfatin is a novel adipokine and unlike Meteorin in adipose and brain expression.CNS neuroscience & therapeutics · 2014Article
- Three statistical experimental designs for enhancing yield of active compounds from herbal medicines and anti-motion sickness bioactivity.Pharmacognosy magazineArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsSome indirect evidences indicate a possible correlation between oxidative stress and motion sickness. The aim of this research was to investigate whether oxidative stress contributing to motion sickness in mice or not.
methodsWe examined the mRNA levels of peroxiredoxin 6 (PRDX6), catalase, and enzyme superoxide dismutase 1 (SOD1); reactive oxygen species (ROS); and total antioxidant capacity and SOD activity in different brain regions after rotary stimulation. Mice motion sickness index was recorded after rotation when pretreated with paraquat, vitamin C, or vitamin E.
resultsThe ROS level and antioxidant capacity were both increased in cerebellum plus brainstem (CB) after rotation, a critical region determines motion sickness. However, manipulation of oxidants or antioxidants using pharmacological method in vivo had no influence on motion sickness index in mice.
conclusionOxidative stress is not involved in the development of motion sickness in mice.
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Registered trials
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