Evidence map›Paper›PMID 23611262›Full record

ArticleBiological psychiatry2013

Fetal glucocorticoid exposure is associated with preadolescent brain development.

Elysia Poggi Davis, Curt A Sandman, Claudia Buss, Deborah A Wing, Kevin Head

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed
29.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 201 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Observational
  8. Article
  9. Linking pregnancy- and birth-related risk factors to a multivariate fusion of child cortical structure.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review

38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Elysia Poggi DavisDepartment of Psychology, University of Denver, Denver, Colorado; Departments of Psychiatry and Human Behavior, University of California Irvine, Orange, California. Electronic address: Elysia.Davis@du.edu.
Curt A Sandman
Claudia Buss
Deborah A Wing
Kevin Head
University of California, Irvine · USUniversity of Denver · US

Funding

Vulnerability to Prenatal Glucocorticoids Programs Infant DevelopmentR01HD065823 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAVIS, ELYSIA POGGI · 2010 to 2014
$2.4M
Prenatal Glucocorticoids Influence Brain and BehaviorR01HD050662 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAVIS, ELYSIA POGGI · 2006 to 2010
$2.0M
NICHD NIH HHS HD050662NICHD NIH HHS HD065823NICHD NIH HHS R01 HD050662NICHD NIH HHS R01 HD065823
6 · The paper itself

Abstract

backgroundGlucocorticoids play a critical role in normative regulation of fetal brain development. Exposure to excessive levels may have detrimental consequences and disrupt maturational processes. This may especially be true when synthetic glucocorticoids are administered during the fetal period, as they are to women in preterm labor. This study investigated the consequences for brain development and affective problems of fetal exposure to synthetic glucocorticoids.

methodsBrain development and affective problems were evaluated in 54 children (56% female), aged 6 to 10, who were full term at birth. Children were recruited into two groups: those with and without fetal exposure to synthetic glucocorticoids. Structural magnetic resonance imaging scans were acquired and cortical thickness was determined. Child affective problems were assessed using the Child Behavior Checklist.

resultsChildren in the fetal glucocorticoid exposure group showed significant and bilateral cortical thinning. The largest group differences were in the rostral anterior cingulate cortex (rACC). More than 30% of the rACC was thinner among children with fetal glucocorticoid exposure. Furthermore, children with more affective problems had a thinner left rACC.

conclusionsFetal exposure to synthetic glucocorticoids has neurologic consequences that persist for at least 6 to 10 years. Children with fetal glucocorticoid exposure had a thinner cortex primarily in the rACC. Our data indicating that the rACC is associated with affective problems in conjunction with evidence that this region is involved in affective disorders raise the possibility that glucocorticoid-associated neurologic changes increase vulnerability to mental health problems.

Indexed as

AdultAtrophyBrainCase-Control StudiesChildFemaleGlucocorticoidsHumansMaleMood DisordersNeuroimagingPregnancyPrenatal Exposure Delayed EffectsGlucocorticoidsDevelopmentfetal programmingglucocorticoidMRIprenatalstress

Identifiers

PMID23611262
PMCPMC3985475
OpenAlexW2133699607

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.