ArticleBone & joint research2013
Local inhibition of 5-lipoxygenase enhances bone formation in a rat model.
Article in Bone & joint research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Vanadium Compound Treatment Modulates MC3t3-E1 Osteoblast Function.International journal of molecular sciences · 2025Article
- PFAS compounds PFOA and Gen X are teratogenic to sea urchin embryos.Developmental biology · 2025Article
- New insights on pharmacological potential of montelukast: a comprehensive review.Inflammopharmacology · 2025Review
- Dose-response effect of Montelukast on post-extraction dental socket repair and skeletal phenotype of mice.Odontology · 2023Article
- The Role of Sex Differences in Bone Health and Healing.Biology · 2023Review
- Sex-Based Difference in Bone Healing: A Review of Recent Pre-clinical Literature.Current reviews in musculoskeletal medicine · 2022Review
- Inhibition of Lipoxygenases Showed No Benefit for the Musculoskeletal System in Estrogen Deficient Rats.Frontiers in endocrinology · 2021Article
- Effect of the lipoxygenase inhibitor baicalein on bone tissue and bone healing in ovariectomized rats.Nutrition & metabolism · 2019Article
- Impact of a local 5-lipoxygenase inhibitor on bone formation during fracture healing.BoneKEy reports · 2013Article
- Locally delivered minocycline microspheres do not impair osseointegration of titanium implants in a rat femur model.Journal of orthopaedicsArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesRecent studies have shown that modulating inflammation-related lipid signalling after a bone fracture can accelerate healing in animal models. Specifically, decreasing 5-lipoxygenase (5-LO) activity during fracture healing increases cyclooxygenase-2 (COX-2) expression in the fracture callus, accelerates chondrogenesis and decreases healing time. In this study, we test the hypothesis that 5-LO inhibition will increase direct osteogenesis.
methodsBilateral, unicortical femoral defects were used in rats to measure the effects of local 5-LO inhibition on direct osteogenesis. The defect sites were filled with a polycaprolactone (PCL) scaffold containing 5-LO inhibitor (A-79175) at three dose levels, scaffold with drug carrier, or scaffold only. Drug release was assessed in vitro. Osteogenesis was assessed by micro-CT and histology at two endpoints of ten and 30 days.
resultsUsing micro-CT, we found that A-79175, a 5-LO inhibitor, increased bone formation in an apparent dose-related manner.
conclusionsThese results indicate that 5-LO inhibition could be used therapeutically to enhance treatments that require the direct formation of bone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.