ArticleProceedings of the National Academy of Sciences of the United States of America2013
Origin of intrinsic irregular firing in cortical interneurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Potential mechanisms and functional significance of aperiodic neural activity.Nature human behaviour · 2026Review
- Characterizing the Diversity of Layer 2/3 Human Neocortical Neurons in Pediatric Epilepsy.eNeuro · 2025Article
- Neuropeptide-Dependent Spike Time Precision and Plasticity in Circadian Output Neurons.The European journal of neuroscience · 2025Article
- Energy dependence of synchronization mode transitions in the delay-coupled FitzHugh-Nagumo system driven by chaotic activity.Cognitive neurodynamics · 2024Article
- Mechanisms of Dominant Electrophysiological Features of Four Subtypes of Layer 1 Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Reverse optogenetics of G protein signaling by zebrafish non-visual opsin Opn7b for synchronization of neuronal networks.Nature communications · 2021Article
- Slowly activating outward membrane currents generate input-output sub-harmonic cross frequency coupling in neurons.Journal of theoretical biology · 2021Article
- Light/Clock Influences Membrane Potential Dynamics to Regulate Sleep States.Frontiers in neurology · 2021Review
- Peripheral nerve injury-induced alterations in VTA neuron firing properties.Molecular brain · 2019Article
- Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome.eLife · 2019Article
- Strength in diversity: functional diversity among olfactory neurons of the same type.Journal of bioenergetics and biomembranes · 2019Review
- Cellular and Network Mechanisms for Temporal Signal Propagation in a Cortical Network Model.Frontiers in computational neuroscience · 2019Article
- Article
- Adult mouse sensory neurons on microelectrode arrays exhibit increased spontaneous and stimulus-evoked activity in the presence of interleukin-6.Journal of neurophysiology · 2018Article
- Highly Heterogeneous Excitatory Connections Require Less Amount of Noise to Sustain Firing Activities in Cortical Networks.Frontiers in computational neuroscience · 2018Article
- Cortical Variability and Challenges for Modeling Approaches.Frontiers in systems neuroscience · 2017Article
- Functional Diversity of Neurotrophin Actions on the Oculomotor System.International journal of molecular sciences · 2016Review
- Stochastic and deterministic dynamics of intrinsically irregular firing in cortical inhibitory interneurons.eLife · 2016Article
- Regulation of Irregular Neuronal Firing by Autaptic Transmission.Scientific reports · 2016Article
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3 authors.
Funding
Abstract
Cortical spike trains are highly irregular both during ongoing, spontaneous activity and when driven at high firing rates. There is uncertainty about the source of this irregularity, ranging from intrinsic noise sources in neurons to collective effects in large-scale cortical networks. Cortical interneurons display highly irregular spike times (coefficient of variation of the interspike intervals >1) in response to dc-current injection in vitro. This is in marked contrast to cortical pyramidal cells, which spike highly irregularly in vivo, but regularly in vitro. We show with in vitro recordings and computational models that this is due to the fast activation kinetics of interneuronal K(+) currents. This explanation holds over a wide parameter range and with Gaussian white, power-law, and Ornstein-Uhlenbeck noise. The intrinsically irregular spiking of interneurons could contribute to the irregularity of the cortical network.
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