ArticleProceedings of the National Academy of Sciences of the United States of America2013
Drosophila ORB protein in two mushroom body output neurons is necessary for long-term memory formation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed, 128 citations in OpenAlex.
- Role of CPEBs in Learning and Memory.Journal of neurochemistry · 2025Review
- In Vivo Imaging of Neural Activity in Unanesthetized Drosophila Adult Flies.Journal of visualized experiments : JoVE · 2025Article
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- Skewing information flow through pre- and postsynaptic plasticity in the mushroom bodies ofLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Roles of feedback and feed-forward networks of dopamine subsystems: insights fromLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Alternative splicing and related RNA binding proteins in human health and disease.Signal transduction and targeted therapy · 2024Review
- Forgotten memory storage and retrieval in Drosophila.Nature communications · 2023Article
- Neural circuit mechanisms for transforming learned olfactory valences into wind-oriented movement.eLife · 2023Article
- 3'UTR of mRNA Encoding CPEB Protein Orb2 Plays an Essential Role in Intracellular Transport in Neurons.Cells · 2023Article
- Cytoplasmic Polyadenylation Is an Ancestral Hallmark of Early Development in Animals.Molecular biology and evolution · 2023Article
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- The cellular architecture of memory modules ineLife · 2023Article
- Article
- Long-Term Memory Formation inCells · 2023Article
- CREBB repression of protein synthesis in mushroom body gates long-term memory formation inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Neuropeptide F inhibits dopamine neuron interference of long-term memory consolidation iniScience · 2021Article
- Prior experience conditionally inhibits the expression of new learning in Drosophila.Current biology : CB · 2021Article
- Models of heterogeneous dopamine signaling in an insect learning and memory center.PLoS computational biology · 2021Article
- Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Memory is initially labile and gradually consolidated over time through new protein synthesis into a long-lasting stable form. Studies of odor-shock associative learning in Drosophila have established the mushroom body (MB) as a key brain structure involved in olfactory long-term memory (LTM) formation. Exactly how early neural activity encoded in thousands of MB neurons is consolidated into protein-synthesis-dependent LTM remains unclear. Here, several independent lines of evidence indicate that changes in two MB vertical lobe V3 (MB-V3) extrinsic neurons are required and contribute to an extended neural network involved in olfactory LTM: (i) inhibiting protein synthesis in MB-V3 neurons impairs LTM; (ii) MB-V3 neurons show enhanced neural activity after spaced but not massed training; (iii) MB-V3 dendrites, synapsing with hundreds of MB α/β neurons, exhibit dramatic structural plasticity after removal of olfactory inputs; (iv) neurotransmission from MB-V3 neurons is necessary for LTM retrieval; and (v) RNAi-mediated down-regulation of oo18 RNA-binding protein (involved in local regulation of protein translation) in MB-V3 neurons impairs LTM. Our results suggest a model of long-term memory formation that includes a systems-level consolidation process, wherein an early, labile olfactory memory represented by neural activity in a sparse subset of MB neurons is converted into a stable LTM through protein synthesis in dendrites of MB-V3 neurons synapsed onto MB α lobes.
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