ArticleDiabetes care2013
Factors associated with microalbuminuria in 7,549 children and adolescents with type 1 diabetes in the T1D Exchange clinic registry.
Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03835312 (Sequential Transplantation of Umbilical Cord Blood Stem Cells and Islet Cells in Children and Adolescents With Monogenic Immunodeficiency Type 1 Diabetes Mellitus), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sequential Transplantation of Umbilical Cord Blood Stem Cells and Islet Cells in Children and Adolescents With Monogenic Immunodeficiency Type 1 Diabetes Mellitus
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
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- Transient albuminuria in the setting of short-term severe hyperglycemia in type 1 diabetes.Journal of diabetes and its complications · 2024Article
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- Evaluation of urinary haptoglobin level as a biomarker of diabetic nephropathy in children with type 1 diabetes.Pediatric nephrology (Berlin, Germany) · 2023Article
- 14. Children and Adolescents: Standards of Care in Diabetes-2023.Diabetes care · 2023Review
- Longitudinal Estimated Glomerular Filtration Rate Trajectories in Children with Type 1 Diabetes.Pediatric diabetes · 2023Article
- Follow-Up Mental Health Care in Youth and Young Adults With Type 1 Diabetes After Positive Depression Screen and/or Suicidal Ideation.Clinical diabetes : a publication of the American Diabetes Association · 2022Article
- Early microvascular complications in type 1 and type 2 diabetes: recent developments and updates.Pediatric nephrology (Berlin, Germany) · 2022Review
- Renal Complications and Duration of Diabetes: An International Comparison in Persons with Type 1 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2021Article
- Sex-Related Differences in Cardiovascular Disease Risk Profile in Children and Adolescents with Type 1 Diabetes.International journal of molecular sciences · 2021Review
- Hemostatic state of children with type 1 diabetes.Annals of pediatric endocrinology & metabolism · 2021Article
- Early functional and metabolic disorders in children with type I diabetes mellitus and diabetic nephropathy.Pediatric endocrinology, diabetes, and metabolism · 2021Article
- Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control.International journal of molecular sciences · 2020Article
- Factors influencing blood pressure and microalbuminuria in children with type 1 diabetes mellitus: salt or sugar?Pediatric nephrology (Berlin, Germany) · 2020Article
- Predicting renal disease progression in a large contemporary cohort with type 1 diabetes mellitus.Diabetologia · 2020Article
- The medical transition of young adults with type 1 diabetes (T1D): a retrospective chart review identifies areas in need of improvement.International journal of pediatric endocrinology · 2020Article
- Vascular Complication in Adolescents With Diabetes Mellitus.Frontiers in endocrinology · 2020Review
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 1 country.
Funding
Abstract
objectiveTo examine factors associated with clinical microalbuminuria (MA) diagnosis in children and adolescents in the T1D Exchange clinic registry. RESEARCH DESIGN AND
methodsT1D Exchange participants <20 years of age with type 1 diabetes ≥ 1 year and urinary albumin-to-creatinine ratio (ACR) measured within the prior 2 years were included in the analysis. MA diagnosis required all of the following: 1) a clinical diagnosis of sustained MA or macroalbuminuria, 2) confirmation of MA diagnosis by either the most recent ACR being ≥ 30 mg/g or current treatment with an ACE inhibitor (ACEI) or angiotensin receptor blocker (ARB), and 3) no known cause for nephropathy other than diabetes. Logistic regression was used to assess factors associated with MA.
resultsMA was present in 329 of 7,549 (4.4%) participants, with a higher frequency associated with longer diabetes duration, higher mean glycosylated hemoglobin (HbA1c) level, older age, female sex, higher diastolic blood pressure (BP), and lower BMI (P ≤ 0.01 for each in multivariate analysis). Older age was most strongly associated with MA among participants with HbA1c ≥ 9.5% (≥ 80 mmol/mol). MA was uncommon (<2%) among participants with HbA1c <7.5% (<58 mmol/mol). Of those with MA, only 36% were receiving ACEI/ARB treatment.
conclusionsOur results emphasize the importance of good glycemic and BP control, particularly as diabetes duration increases, in order to reduce the risk of nephropathy. Since age and diabetes duration are important nonmodifiable factors associated with MA, the importance of routine screening is underscored to ensure early diagnosis and timely treatment of MA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.