ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2013
Functional anatomy of outcome evaluation during Iowa Gambling Task performance in patients with Parkinson's disease: an fMRI study.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- The Iowa Gambling Task: Men and Women Perform Differently. A Meta-analysis.Neuropsychology review · 2025Pooled it
- Decision making in Parkinson's disease: An analysis of the studies using the Iowa Gambling Task.The European journal of neuroscience · 2021Pooled it
- Cerebellar Contribution to Motor and Non-motor Functions in Parkinson's Disease: A Meta-Analysis of fMRI Findings.Frontiers in neurology · 2020Pooled it
- Is there a Neurobiological Rationale for the Utility of the Iowa Gambling Task in Parkinson's Disease?Journal of Parkinson's disease · 2021Review
- Neural Encoding of the Reliability of Directional Information During the Preparation of Targeted Movements.Frontiers in neuroscience · 2021Article
- The Impact of Compulsivity and Impulsivity in Cerebellar Ataxia: A Case Series.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Article
- Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease.Frontiers in neurology · 2019Article
- Functional MRI on executive functioning in aging and dementia: A scoping review of cognitive tasks.Aging medicine (Milton (N.S.W)) · 2018Article
- Decision-making in primary onset middle-age type 2 diabetes mellitus: a BOLD-fMRI study.Scientific reports · 2017Article
- Age-related differences in advantageous decision making are associated with distinct differences in functional community structure.Brain connectivity · 2014Article
- Decision and dopaminergic system: an ERPs study of Iowa gambling task in Parkinson's disease.Frontiers in psychology · 2014Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the functional anatomy of decision-making during the Iowa Gambling Task in patients with Parkinson's disease. We used event-related functional magnetic resonance imaging (fMRI) during a computerized version of IGT to compare 18 PD patients on dopaminergic medication in the ON state and 18 healthy control subjects. Our analyses focused on outcome evaluation following card selection, because we expected this aspect of decision-making to be impaired in PD patients. The PD patients exhibited lower activation of the left putamen than the control group as a reaction to penalty. Using psychophysiological interaction analysis, we identified decreased functional connectivity between the right globus pallidus internus and the left anterior cingulate gyrus in the PD group. In contrast, increased connectivity between these structures was observed after penalty in the control group. Our results suggest altered functioning of the basal ganglia and their connections with the cortical structures involved in the limbic loop (e.g., the limbic fronto-striatal circuit of the basal ganglia) during decision-making in PD patients. Differences in the response to loss could be associated with insufficient negative reinforcement after a loss in PD patients in the ON state in comparison to a healthy population.
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