Evidence map›Paper›PMID 23609157›Full record

ArticleBehavior genetics2013

DNA evidence for strong genome-wide pleiotropy of cognitive and learning abilities.

Maciej Trzaskowski, Oliver S P Davis, John C DeFries, Jian Yang, Peter M Visscher, Robert Plomin

Abstract readTwin Study
In one paragraph

Article in Behavior genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

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  20. Genetic influences on adolescent behavior.Neuroscience and biobehavioral reviews · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maciej TrzaskowskiMRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, DeCrespigny Park, Denmark Hill, London, SE5 8AF, UK. maciej.trzaskowski@kcl.ac.uk
Oliver S P Davis
John C DeFries
Jian Yang
Peter M Visscher
Robert Plomin

Funding

Genetics, School environments and cognitive developmentR01HD044454 · NICHD · KING'S COLLEGE LONDON · PI PLOMIN, ROBERT · 2005 to 2014
$3.4M
GENETICS OF GENERAL AND SPECIFIC MATH DISABILITIESR01HD046167 · NICHD · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI PETRILL, STEPHEN A · 2003 to 2005
$1.6M
European Research Council 295366Medical Research Council G0500079Medical Research Council G0500079(73692)Medical Research Council G0901245Medical Research Council G19/2Medical Research Council G19/2(78332)NICHD NIH HHS HD044454NICHD NIH HHS HD046167NICHD NIH HHS R01 HD044454NICHD NIH HHS R01 HD046167Wellcome TrustWellcome Trust 085475/B/08/ZWellcome Trust 085475/Z/08/ZWellcome Trust WT088984
6 · The paper itself

Abstract

Very different neurocognitive processes appear to be involved in cognitive abilities such as verbal and non-verbal ability as compared to learning abilities taught in schools such as reading and mathematics. However, twin studies that compare similarity for monozygotic and dizygotic twins suggest that the same genes are largely responsible for genetic influence on these diverse aspects of cognitive function. It is now possible to test this evidence for strong pleiotropy using DNA alone from samples of unrelated individuals. Here we used this new method with 1.7 million DNA markers for a sample of 2,500 unrelated children at age 12 to investigate for the first time the extent of pleiotropy between general cognitive ability (aka intelligence) and learning abilities (reading, mathematics and language skills). We also compared these DNA results to results from twin analyses using the same sample and measures. The DNA-based method revealed strong genome-wide pleiotropy: Genetic correlations were greater than 0.70 between general cognitive ability and language, reading, and mathematics, results that were highly similar to twin study estimates of genetic correlations. These results indicate that genes related to diverse neurocognitive processes have general rather than specific effects.

Indexed as

Genetic PleiotropyChildCognitionDNAEnglandFemaleGenetic MarkersGenome, HumanGenome-Wide Association StudyHumansIntelligenceIntelligence TestsLanguageLearningLongitudinal StudiesMaleDNAGenetic Markers

Identifiers

PMID23609157
PMCPMC3690183

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.