ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2013
Peroral endoscopic myotomy (POEM) is safe and effective in the setting of prior endoscopic intervention.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 4 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Efficacy and Safety of Peroral Endoscopic Myotomy in Achalasia Patients with Failed Previous Intervention: A Systematic Review and Meta-Analysis.Gut and liver · 2021Pooled it
- Safety and efficacy of POEM for treatment of achalasia: a systematic review of the literature.Surgical endoscopy · 2017Pooled it
- Surgery or Peroral Esophageal Myotomy for Achalasia: A Systematic Review and Meta-Analysis.Medicine · 2016Pooled it
- Efficacy of peroral endoscopic myotomy (POEM) in the treatment of achalasia: a systematic review and meta-analysis.Surgical endoscopy · 2015Pooled it
- Gastrointestinal Uses of Botulinum Toxin.Handbook of experimental pharmacology · 2021Trial
- Double-scope per oral endoscopic myotomy (POEM): a prospective randomized controlled trial.Surgical endoscopy · 2016Trial
- Evolving therapeutic approaches in achalasia: a comprehensive review of peroral endoscopic myotomy (POEM) vs. Heller's myotomy.Annals of medicine and surgery (2012) · 2025Review
- Peroral endoscopic myotomy for complex achalasia and the POEM difficulty score: An update.DEN open · 2025Article
- Peroral endoscopic myotomy: is it better to perform it in naive patients or as second-line therapy? Results of an open-label-controlled study in 105 patients.Surgical endoscopy · 2023Article
- Peroral endoscopic myotomy for the treatment of achalasia after failed pneumatic dilation.Surgical endoscopy · 2021Article
- Peroral endoscopic myotomy is highly effective for achalasia patients with recurrent symptoms after pneumatic dilatation.Surgical endoscopy · 2021Article
- Comparison of peroral endoscopic myotomy between de-novo achalasia and achalasia with prior treatment.Surgical endoscopy · 2021Article
- Hybrid Peroral Endoscopic Myotomy for Achalasia with Prior Treatment Failure.Clinical endoscopy · 2021Article
- Peroral Endoscopic Myotomy, a Well-Established, Efficacious, and Safe Treatment Option for Achalasia: Is the History of Previous Treatment a Hurdle or Not?Clinical endoscopy · 2020Article
- Peroral Endoscopic Myotomy as a Novel Treatment for Achalasia: Patient Selection and Perspectives.Clinical and experimental gastroenterology · 2020Review
- Peroral endoscopic myotomy (POEM) for achalasia.Journal of thoracic disease · 2019Review
- The Role of Botulinum Toxin Injections for Esophageal Motility Disorders.Current treatment options in gastroenterology · 2018Review
- Per oral endoscopic myotomy: early experience and safety of a multispecialty approach.Surgical endoscopy · 2018Article
- Current Status of Peroral Endoscopic Myotomy.Clinical endoscopy · 2018Review
- Per-oral endoscopic myotomy for achalasia cardia: outcomes in over 400 consecutive patients.Endoscopy international open · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to determine the safety and feasibility of peroral endoscopic myotomy (POEM) in the setting of prior endoscopic interventions. PATIENTS: This study involves 40 consecutive patients undergoing POEM.
interventionPOEM was performed for esophageal motility disorders, including achalasia, nutcracker with nonrelaxing lower esophageal sphincter (LES), hypertensive lower esophageal sphincter, and diffuse esophageal spasm.
main outcome measuresOutcome measures include length of procedure (LOP), intraoperative complications, and dysphagia relief.
resultsForty patients, with a mean age of 54 ± 19 years, underwent POEM. The pre-POEM intervention group consisted of 12 patients (nine achalasia, two nutcracker with nonrelaxing LES, and one diffuse esophageal spasm) who also had previous endoscopic treatment, while the pre-POEM non-intervention group consisted of 28 patients (22 achalasia, 3 hypertensive LES, 2 nutcracker with nonrelaxing LES, and 1 diffuse esophageal spasm). Ten patients had botox injections and two patients had large caliber balloon dilations prior to POEM. The median preoperative Eckardt score was 5 in the pre-POEM intervention group vs 6 in the pre-POEM non-intervention group (p value = 0.4). There was no statistical difference in the mean LOP (134 ± 43 vs 131 ± 41, p = 0.8) or the incidence of intraoperative complications (17 vs 3 %, p = 0.2) between the two groups. There was also no difference in the 6-month postoperative median Eckardt scores between the two groups (1 vs 1, p = 0.4).
conclusionPOEM is safe and effective even following preoperative endoscopic large caliber balloon dilations or botox injection. These interventions do not seem to contribute to increased adverse intraoperative or postoperative clinical outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.