ReviewImmunologic research2013
Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity.
Review in Immunologic research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 266 citations in OpenAlex.
- Trial
- Human Health Risk Assessment of Potentially Toxic Metals and Natural Radionuclides in Unrefined Edible Salts from Salt Mining Communities of Nasarawa State, Nigeria.Biological trace element research · 2026Article
- Rethinking Neonatal Vaccination Policies: A Neuroimmune Perspective.Iranian journal of medical sciences · 2026Review
- Comparative analysis reveals distinct metal and inflammatory cytokine profiles in the cerebrospinal fluid of children with neurological disorders.Frontiers in toxicology · 2026Article
- The Values of Potentially Toxic Elements (PTEs) in Prescription and Non-prescription Dry Cat and Dog Diets in Turkey.Biological trace element research · 2026Article
- Silica Nanoparticles from Melon Seed Husk Abrogated Binary Metal(loid) Mediated Cerebellar Dysfunction by Attenuation of Oxido-inflammatory Response and Upregulation of Neurotrophic Factors in Male Albino Rats.Cerebellum (London, England) · 2024Article
- Next-generation aluminum adjuvants: Immunomodulatory layered double hydroxide NanoAlum reengineered from first-line drugs.Acta pharmaceutica Sinica. B · 2024Review
- Zeolite and Neurodegenerative Diseases.Molecules (Basel, Switzerland) · 2024Review
- Bee pollen as a food and feed supplement and a therapeutic remedy: recent trends in nanotechnology.Frontiers in nutrition · 2024Review
- Aluminum Biorecovery from Wastewaters.Advances in biochemical engineering/biotechnology · 2024Review
- Additive aluminum as a cause of induced immunoexcitoxicity resulting in neurodevelopmental and neurodegenerative disorders: A biochemical, pathophysiological, and pharmacological analysis.Surgical neurology international · 2024Article
- Review
- Toxic element contaminations of prenatal vitamins.Toxicology and applied pharmacology · 2023Article
- Dietary intervention with functional foods modulating gut microbiota for improving the efficacy of COVID-19 vaccines.Heliyon · 2023Review
- Potentially toxic elements in the brains of people with multiple sclerosis.Scientific reports · 2023Article
- PEO Coatings Modified with Halloysite Nanotubes: Composition, Properties, and Release Performance.International journal of molecular sciences · 2022Article
- Trace Element Changes in the Plasma of Autism Spectrum Disorder Children and the Positive Correlation Between Chromium and Vanadium.Biological trace element research · 2022Article
- Nano alum: A new solution to the new challenge.Human vaccines & immunotherapeutics · 2022Review
- Metals and Metalloids Increase inToxics · 2022Article
- Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have examined the neurotoxicity of aluminum in humans and animals under various conditions, following different routes of administration, and provide an overview of the various associated disease states. The literature demonstrates clearly negative impacts of aluminum on the nervous system across the age span. In adults, aluminum exposure can lead to apparently age-related neurological deficits resembling Alzheimer's and has been linked to this disease and to the Guamanian variant, ALS-PDC. Similar outcomes have been found in animal models. In addition, injection of aluminum adjuvants in an attempt to model Gulf War syndrome and associated neurological deficits leads to an ALS phenotype in young male mice. In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.