ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2013
Transcription factor STAT1 gene polymorphism is associated with the development of severe forms of periodontal disease.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- STAT1 maintains naïve CD8Science advances · 2021Article
- Periodontitis aggravates kidney injury by upregulating STAT1 expression in a mouse model of hypertension.FEBS open bio · 2021Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
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Abstract
introductionPeriodontal disease (PD) is one of the most common inflammatory diseases, affecting about 10 % of the world population. The establishment of PD is influenced by polymorphisms in genes involved with the inflammatory response. Signal Transducer and Activator of Transcription (STAT)-1 is a transcription factor that plays a key role in the intracellular signaling triggered by cytokines and, thus, its activation is critical in inflammatory diseases. AIM AND
methodsWe aim to evaluate the occurrence of association between STAT-1 (rs3771300) polymorphism and distinct clinical forms and severity of PD; we genotyped 180 subjects using realtime PCR. RESULTS AND
conclusionWe observed that the presence of the G allele for STAT-1 was associated with twice as high of a chance to develop aggressive periodontitis, and the most severe form of the disease.
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