SynthesisTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2013
Glutathione S-transferase T1 null genotype is associated with oral cancer susceptibility in Asian populations.
Synthesis in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Glutathione S-transferase theta 1 (GSTT1) deletion polymorphism and susceptibility to head and neck carcinoma: a systematic review with five analyses.BMC cancer · 2024Pooled it
- Genetic Polymorphisms of Multidrug Resistance Gene-1 (MDR1/ABCB1) and Glutathione S-Transferase Gene and the Risk of Inflammatory Bowel Disease among Moroccan Patients.Mediators of inflammation · 2015Pooled it
- Glutathione S-transferase T1 null genotype and laryngeal cancer risk: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- XRCC1 Arg399Gln polymorphism is not associated with oral cancer risk: evidence from a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Association of Glutathione-S-Transferases M1 and T1 Deletional Variants with Development of Oral Squamous Cell Carcinoma: A Study in the South-East of Iran.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Association of glutathione S-transferase (GSTM1 and GSTT1) genes with chronic myeloid leukemia.SpringerPlus · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Though there are many studies assessing the association between glutathione S-transferase T1 (GSTT1) null genotype and oral cancer risk, the association between GSTT1 null genotype and oral cancer in Asian populations is still inconclusive. We performed a meta-analysis of 19 studies including 2,845 cases and 4,295 controls to derive a more precise estimation of the relationship. The pooled odds ratio (OR) with its corresponding 95 % confidence interval (95 % CI) was used to assess the relationship. Meta-analysis of those 19 studies suggested that there was an association between GSTT1 null genotype and elevated risk of oral cancer risk (OR = 1.25, 95 % CI = 1.00-1.56, P = 0.047). Sensitivity analysis by omitting one study at a time showed that the significance of the corresponding pooled ORs was materially altered frequently, indicating that the pooled ORs were not statistically stable. In addition, there was no obvious risk of publication bias in the meta-analysis. Therefore, the present meta-analysis suggests that the GSTT1 null genotype is a risk allele for oral cancer development in Asian populations, but more studies with large sample and well-matched controls are needed to further confirm the finding from the meta-analysis.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.