Evidence map›Paper›PMID 23608919›Full record

ArticleMolecular psychiatry2014

Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits.

C C Y Wong, E L Meaburn, A Ronald, T S Price, A R Jeffries, L C Schalkwyk, R Plomin, J Mill

Registry-linked trialOpen access · hybridAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02469428 (Epigenetic Effect Modifications With Ozone Exposure on Healthy Volunteers), which is not on this map. Cited by 162 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed, 8 pooled it
17.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02469428 nacompletednot on this map

Epigenetic Effect Modifications With Ozone Exposure on Healthy Volunteers

TypeinterventionalSponsorEnvironmental Protection Agency (EPA)Ran2013 to 2018Enrolled14ConditionsExposure to Environmental Pollution, Non-occupationalArmsClean air, Ozone
3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 8 syntheses or guidelines pooled it, 328 citations in OpenAlex.

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  20. Rodent Models for ASD Biomarker Development.Advances in neurobiology · 2024
    Review

102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

C C Y WongKing's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK.
E L Meaburn1] King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK [2] Department of Psychological Sciences, Birkbeck, University of London, London, UK.
A Ronald1] King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK [2] Department of Psychological Sciences, Birkbeck, University of London, London, UK.
T S Price1] King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK [2] Institute of Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, PA, USA.
A R JeffriesKing's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK.
L C SchalkwykKing's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK.
R PlominKing's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK.
J Mill1] King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK [2] University of Exeter Medical School, Exeter University, St Luke's Campus, Exeter, UK.
King's College London · GBUniversity of Exeter · GB

Funding

Genetics, School environments and cognitive developmentR01HD044454 · NICHD · KING'S COLLEGE LONDON · PI PLOMIN, ROBERT · 2005 to 2014
$3.4M
GENETICS OF GENERAL AND SPECIFIC MATH DISABILITIESR01HD046167 · NICHD · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI PETRILL, STEPHEN A · 2003 to 2005
$1.6M
Department of HealthEuropean Research Council 295366Medical Research Council G0500079Medical Research Council G0500079(73692)Medical Research Council G0901245Medical Research Council G19/2Medical Research Council G19/2(78332)NICHD NIH HHS HD044454NICHD NIH HHS HD046167NICHD NIH HHS R01 HD044454NICHD NIH HHS R01 HD046167
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) defines a group of common, complex neurodevelopmental disorders. Although the aetiology of ASD has a strong genetic component, there is considerable monozygotic (MZ) twin discordance indicating a role for non-genetic factors. Because MZ twins share an identical DNA sequence, disease-discordant MZ twin pairs provide an ideal model for examining the contribution of environmentally driven epigenetic factors in disease. We performed a genome-wide analysis of DNA methylation in a sample of 50 MZ twin pairs (100 individuals) sampled from a representative population cohort that included twins discordant and concordant for ASD, ASD-associated traits and no autistic phenotype. Within-twin and between-group analyses identified numerous differentially methylated regions associated with ASD. In addition, we report significant correlations between DNA methylation and quantitatively measured autistic trait scores across our sample cohort. This study represents the first systematic epigenomic analyses of MZ twins discordant for ASD and implicates a role for altered DNA methylation in autism.

Indexed as

DNA MethylationChildChild Development Disorders, PervasiveCohort StudiesCpG IslandsDiseases in TwinsEpigenomicsFemaleGene Expression ProfilingGenome-Wide Association StudyHumansMaleMental DisordersOligonucleotide Array Sequence AnalysisPhenotypePsychiatric Status Rating Scales

Identifiers

PMID23608919
PMCPMC3906213
OpenAlexW2148118486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.