ReviewRespiratory physiology & neurobiology2013
Chemoreception and asphyxia-induced arousal.
Review in Respiratory physiology & neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Trazodone improves obstructive sleep apnea after ischemic stroke: a randomized, double-blind, placebo-controlled, crossover pilot study.Journal of neurology · 2021Trial
- Glycemic Challenge Is Associated with the Rapid Cellular Activation of the Locus Ceruleus and Nucleus of Solitary Tract: Circumscribed Spatial Analysis of Phosphorylated MAP Kinase Immunoreactivity.Journal of clinical medicine · 2023Article
- In vivo structural connectome of arousal and motor brainstem nuclei by 7 Tesla and 3 Tesla MRI.Human brain mapping · 2022Article
- Amygdala-driven apnea and the chemoreceptive origin of anxiety.Biological psychology · 2022Review
- Chemoreceptor mechanisms regulating COThe Journal of physiology · 2021Review
- Interaction Between Arousals and Ventilation During Cheyne-Stokes Respiration in Heart Failure Patients: Insights From Breath-by-Breath Analysis.Frontiers in medicine · 2021Article
- Neurohumoral Cardiac Regulation: Optogenetics Gets Into the Groove.Frontiers in physiology · 2021Review
- Nocturnal swallowing augments arousal intensity and arousal tachycardia.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Take a deep breath and wake up: The protean role of serotonin preventing sudden death in infancy.Experimental neurology · 2020Review
- Serotonin and sudden unexpected death in epilepsy.Experimental neurology · 2020Review
- Contribution of the Retrotrapezoid Nucleus and Carotid Bodies to Hypercapnia- and Hypoxia-induced Arousal from Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Impaired COTrends in neurosciences · 2019Review
- Afferent neural feedback overrides the modulating effects of arousal, hypercapnia and hypoxaemia on neonatal cardiorespiratory control.The Journal of physiology · 2018Article
- Dorsal Raphe Serotonin Neurons Mediate COThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Panic Anxiety in Humans with Bilateral Amygdala Lesions: Pharmacological Induction via Cardiorespiratory Interoceptive Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Neural Control of Breathing and CO2 Homeostasis.Neuron · 2015Review
- 5-HT2A receptor activation is necessary for CO2-induced arousal.Journal of neurophysiology · 2015Article
- Optogenetic stimulation of adrenergic C1 neurons causes sleep state-dependent cardiorespiratory stimulation and arousal with sighs in rats.American journal of respiratory and critical care medicine · 2014Article
- Regulation of breathing and autonomic outflows by chemoreceptors.Comprehensive Physiology · 2014Review
- Sleep and breathing. Foreword.Respiratory physiology & neurobiology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Arousal protects against the adverse and potentially fatal effects of asphyxia during sleep. Asphyxia stimulates the carotid bodies and central chemoreceptors but the sequence of events leading to arousal is uncertain. In this review, the theoretical mechanisms leading to arousal from sleep are briefly summarized and the issue of whether central respiratory chemoreceptors (CRCs) or other types of CO2-responsive CNS neurons contribute to asphyxia-induced arousal is discussed. We focus on the role of the retrotrapezoid nucleus, the raphe and the locus coeruleus and emphasize the anatomical and neurophysiological evidence which suggests that these putative central chemoreceptors could contribute to arousal independently of their effects on breathing. Finally, we describe recent attempts to test the contribution of specific brainstem pathways to asphyxia-induced arousal using optogenetic and other tools and the possible contribution of a group of hypoxia-sensitive brainstem neurons (the C1 cells) to breathing and arousal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.