ArticleHeart rhythm2013
Feasibility of image-based simulation to estimate ablation target in human ventricular arrhythmia.
Article in Heart rhythm, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.
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Who cites it
91 citing papers in PubMed, 1 synthesis or guideline pooled it, 136 citations in OpenAlex.
- Prognostic value of myocardial fibrosis on cardiac magnetic resonance imaging in patients with ischemic cardiomyopathy: A systematic review.American heart journal · 2020Pooled it
- An eikonal model with re-excitability for fast simulations in cardiac electrophysiology.The Journal of physiology · 2026Article
- The Hodgkin-Huxley-Katz Prize Lecture: Heart digital twins: A new paradigm in arrhythmia medicine.The Journal of physiology · 2026Article
- In silico predictions of action potential propagation in doxorubicin cardiotoxicity: A parametric study using preclinical 3D magnetic resonance imaging-based fibrotic left ventricle models.The Journal of physiology · 2026Article
- Cardiac magnetic resonance imaging in patients referred for premature ventricular contractions: identifying patients most likely to benefit.Frontiers in cardiovascular medicine · 2026Article
- Heart Digital Twins Predict Features of Invasive Reentrant Circuits and Ablation Lesions in Scar-Dependent Ventricular Tachycardia.Circulation. Arrhythmia and electrophysiology · 2025Article
- Digital twins as global learning health and disease models for preventive and personalized medicine.Genome medicine · 2025Review
- Medical Digital Twin: A Review on Technical Principles and Clinical Applications.Journal of clinical medicine · 2025Review
- Current trends in virtual electrophysiology use for risk stratification and treatment of ventricular arrhythmias.Frontiers in cardiovascular medicine · 2025Review
- Complication detection in MRI guided cardiac ablation: Atrial wall damage and hepatic oedema.Radiology case reports · 2024Article
- Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation.Physiological reviews · 2024Review
- Digital twins for cardiac electrophysiology: state of the art and future challenges.Herzschrittmachertherapie & Elektrophysiologie · 2024Review
- Digital twins in medicine.Nature computational science · 2024Review
- Up digital and personal: How heart digital twins can transform heart patient care.Heart rhythm · 2024Review
- Initial experience on cardiac magnetic resonance-aided VT ablation in South America.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023Article
- Arrhythmogenic vulnerability of re-entrant pathways in post-infarct ventricular tachycardia assessed by advanced computational modelling.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Optogenetic Modulation of Arrhythmia Triggers: Proof-of-Concept from Computational Modeling.Cellular and molecular bioengineering · 2023Article
- Fat infiltration in the infarcted heart as a paradigm for ventricular arrhythmias.Nature cardiovascular research · 2022Article
- The physics of heart rhythm disorders.Physics reports · 2022Article
- An automated near-real time computational method for induction and treatment of scar-related ventricular tachycardias.Medical image analysis · 2022Article
31 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies suggest that magnetic resonance imaging with late gadolinium enhancement (LGE) may identify slowly conducting tissues in scar-related ventricular tachycardia (VT).
objectiveTo test the feasibility of image-based simulation based on LGE to estimate ablation targets in VT.
methodsWe conducted a retrospective study in 13 patients who had preablation magnetic resonance imaging for scar-related VT ablation. We used image-based simulation to induce VT and estimate target regions according to the simulated VT circuit. The estimated target regions were coregistered with the LGE scar map and the ablation sites from the electroanatomical map in the standard ablation approach.
resultsIn image-based simulation, VT was inducible in 12 (92.3%) patients. All VTs showed macroreentrant propagation patterns, and the narrowest width of estimated target region that an ablation line should span to prevent VT recurrence was 5.0 ± 3.4 mm. Of 11 patients who underwent ablation, the results of image-based simulation and the standard approach were consistent in 9 (82%) patients, where ablation within the estimated target region was associated with acute success (n = 8) and ablation outside the estimated target region was associated with failure (n = 1). In 1 (9%) case, the results of image-based simulation and the standard approach were inconsistent, where ablation outside the estimated target region was associated with acute success.
conclusionsThe image-based simulation can be used to estimate potential ablation targets of scar-related VT. The image-based simulation may be a powerful noninvasive tool for preprocedural planning of ablation procedures to potentially reduce the procedure time and complication rates.
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