Evidence map›Paper›PMID 23608224›Full record

ReviewThe American journal of pathology2013

Biological relevance of inflammation and oxidative stress in the pathogenesis of arterial diseases.

David P Hajjar, Antonio M Gotto

Open access · bronzeAbstract readReview
In one paragraph

Review in The American journal of pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 156 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Ginsenoside RbChinese herbal medicines · 2024
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Delphinidin-3-Pharmaceutical biology · 2022
    Article
  18. The CCR2Journal of cardiovascular development and disease · 2022
    Article
  19. Article
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

David P HajjarDepartment of Biochemistry, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA. dphajjar@med.cornell.edu
Antonio M Gotto
Cornell University · US

Funding

Vascular signaling via scavenger receptorsP01HL046403 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI HAJJAR, DAVID P · 1991 to 2011
$26.7M
Eicosanoid Regulation in Atherosclerosis: Involvement of Inducible NO SynthaseR01HL091101 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI HAJJAR, DAVID P · 2009 to 2010
$858k
NHLBI NIH HHS P01 HL046403NHLBI NIH HHS P01 HL-46403NHLBI NIH HHS R01 HL-091101NHLBI NIH HHS R01 HL091101
6 · The paper itself

Abstract

Over the past three decades, age-adjusted rates of cardiovascular morbidity and mortality have fallen in the United States, but the prevalence of obesity and associated metabolic disorders has risen dramatically. Recent studies have begun to unravel the complex linkages between adipose and vascular tissues that may accelerate the development of atherosclerosis in the context of obesity. Experimental models indicate that inflammation and oxidative stress, which mutually amplify each other within the vasculature and in visceral fat, are key processes that drive the initiation, progression, and subsequent rupture of the atherosclerotic lesion. Emerging research is further elucidating the contributions made by chemokines and their receptors, adipokines, and miRNAs to arterial disease. Translation of these basic science findings to clinical applications represents a tantalizing possibility for reducing the global burden of obesity-associated atherosclerosis and other cardiovascular diseases.

Indexed as

Oxidative StressAnimalsAtherosclerosisBiomarkersHumansInflammationObesityVascular DiseasesBiomarkers

Identifiers

PMID23608224
PMCPMC3644714
OpenAlexW2086036056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.