ArticleBiological psychiatry2013
Cell number and neuropil alterations in subregions of the anterior hippocampus in a female monkey model of depression.
Article in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Vascular endothelial growth factor: a key factor in the onset and treatment of depression.Frontiers in cellular neuroscience · 2025Review
- Not Just a Mood Disorder─Is Depression a Neurodevelopmental, Cognitive Disorder? Focus on Prefronto-Thalamic Circuits.ACS chemical neuroscience · 2024Review
- The Role of the Adrenal-Gut-Brain Axis on Comorbid Depressive Disorder Development in Diabetes.Biomolecules · 2023Review
- Recent Studies on the Development of Nicotine Abuse and Behavioral Changes Induced by Chronic Stress Depending on Gender.Brain sciences · 2023Review
- The Neurobiological Effects of Electroconvulsive Therapy Studied Through Magnetic Resonance: What Have We Learned, and Where Do We Go?Biological psychiatry · 2022Review
- Relationship between VEGF-related gene polymorphisms and brain morphology in treatment-naïve patients with first-episode major depressive disorder.European archives of psychiatry and clinical neuroscience · 2019Article
- Adult neuroplasticity: A new “cure” for major depression?Journal of psychiatry & neuroscience : JPN · 2019Article
- COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder.Neuropsychiatric disease and treatment · 2019Article
- Post-mortem inference of the human hippocampal connectivity and microstructure using ultra-high field diffusion MRI at 11.7 T.Brain structure & function · 2018Article
- A Key Role for Subiculum-Fornix Connectivity in Recollection in Older Age.Frontiers in systems neuroscience · 2018Article
- Hippocampal GABAergic Inhibitory Interneurons.Physiological reviews · 2017Review
- Relationship between cerebellar structure and emotional memory in depression.Brain and behavior · 2017Article
- Hippocampal volume changes following electroconvulsive therapy: a systematic review and meta-analysis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
- Reduced marker of vascularization in the anterior hippocampus in a female monkey model of depression.Physiology & behavior · 2017Article
- Rapid antidepressant effect of ketamine correlates with astroglial plasticity in the hippocampus.British journal of pharmacology · 2017Article
- The impact of treatment with selective serotonin reuptake inhibitors on primate cardiovascular disease, behavior, and neuroanatomy.Neuroscience and biobehavioral reviews · 2017Review
- Stress, sex, and motivated behaviors.Journal of neuroscience research · 2017Review
- Density of GFAP-immunoreactive astrocytes is decreased in left hippocampi in major depressive disorder.Neuroscience · 2016Article
- Long term sertraline effects on neural structures in depressed and nondepressed adult female nonhuman primates.Neuropharmacology · 2015Article
- Naltrexone treatment reverses astrocyte atrophy and immune dysfunction in self-harming macaques.Brain, behavior, and immunity · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe anterior hippocampus is associated with emotional functioning and hippocampal volume is reduced in depression. More women are clinically depressed than men, yet the depressed female brain is little studied. We reported reduced anterior hippocampal volume in behaviorally depressed adult female cynomolgus macaques; the mechanisms contributing to that reduction are unknown. The present study represents the first systematic morphological investigation of the entire hippocampus in depressed female primates.
methodsCellular determinants of hippocampal size were examined in subregions of anterior and posterior hippocampus in antidepressant-naïve, adult female monkeys characterized for behavioral depression and matched on variables that influence hippocampal size (n = 8 depressed, 8 nondepressed). Unbiased stereology was used to estimate neuronal and glial numbers, neuronal soma size, and regional and layer volumes.
resultsNeuropil and cell layer volumes were reduced in cornu ammonis (CA)1 and dentate gyrus (DG) of the anterior but not the posterior hippocampus of depressed compared with nondepressed monkeys. Glial numbers were 30% lower in anterior CA1 and DG of depressed monkeys, with no differences observed in the posterior hippocampus. Granule neuron number tended toward a reduction in anterior DG; pyramidal neuron number was unchanged in any region. Size of pyramidal neurons and glial densities tended to be reduced throughout the whole hippocampus of depressed monkeys, whereas neuronal densities were unchanged.
conclusionsThe reduced size of the anterior hippocampus in depressed female monkeys appears to arise from alterations in numbers of glia and extent of neuropil, but not numbers of neurons, in CA1 and DG.
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