ReviewHelicobacter2013
Helicobacter pylori infection--a boon or a bane: lessons from studies in a low-prevalence population.
Review in Helicobacter, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 68 citations in OpenAlex.
- Synthesis, Characterization, and Evaluation of Palladium(II) Complexes Containing Chalcones on Gastric Adenocarcinoma Cells andACS omega · 2026Article
- Cultivation and molecular characterization of viable Helicobacter pylori from the root canal of 170 deciduous teeth of children.Cell communication and signaling : CCS · 2024Article
- Poly-β-hydroxybutyrate alleviated diarrhea and colitis via Lactobacillus johnsonii biofilm-mediated maturation of sulfomucin.Science China. Life sciences · 2023Article
- Dual infective burden of Helicobacter pylori and intestinal parasites: Good or bad news for the host?Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Review
- Review
- Association of Helicobacter pylori infection with gastroesophageal reflux disease.The Journal of international medical research · 2019Article
- Systematic Review with Meta-analysis: Association of Helicobacter pylori Infection with Esophageal Cancer.Gastroenterology research and practice · 2019Review
- Warthin-Starry Staining for the Detection ofThe Malaysian journal of medical sciences : MJMS · 2018Article
- Helicobacter pylori induces caudal-type homeobox protein 2 and cyclooxygenase 2 expression by modulating microRNAs in esophageal epithelial cells.Cancer science · 2018Article
- Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence.PloS one · 2018Article
- The prevalence ofGut pathogens · 2018Article
- Helicobacter pylori infection increases the risk of adult-onset asthma: a nationwide cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- A Comparative Study of Efficacy and Safety of Two Eradication Regimens for Helicobacter pylori Infection.Maedica · 2017Article
- Consensus on the clinical management, screening-to-treat, and surveillance of Helicobacter pylori infection to improve gastric cancer control on a nationwide scale.Helicobacter · 2017Article
- Review
- Helicobacter pylori outer membrane protein and virulence marker differences in expatriate patients.Epidemiology and infection · 2016Article
- Helicobacter pylori associated gastric intestinal metaplasia: Treatment and surveillance.World journal of gastroenterology · 2016Review
- Food Allergy and Helicobacter pylori Infection: A Systematic Review.Frontiers in microbiology · 2016Review
- Systematic review of time trends in the prevalence of Helicobacter pylori infection in China and the USA.Gut pathogens · 2016Review
- The diagnosis and treatment of Helicobacter pylori infection in Arctic regions with a high prevalence of infection: Expert Commentary.Epidemiology and infection · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Helicobacter pylori (H. pylori) infection is etiologically associated with gastric cancer and peptic ulcer diseases which are both important public health burdens which could be largely eliminated by H. pylori eradication. However, some investigators urge caution based on the hypothesis that eradication of H. pylori may result in an increase in the incidence of gastroesophageal reflux disease, esophageal adenocarcinoma, and childhood asthma. The ethnic Malays of northeastern Peninsular Malaysia have long had a low prevalence of H. pylori infection and, as expected, the incidence of gastric cancer and its precursor lesions is exceptionally low. The availability of a population with a low H. pylori prevalence and generally poor sanitation allows separation of H. pylori from the hygiene hypothesis and direct testing of whether absence of H. pylori is associated with untoward consequence. Contrary to predictions, in Malays, erosive esophagitis, Barrett's esophagus, distal esophageal cancers, and childhood asthma are all of low incidence. This suggests that H. pylori is not protective rather the presence of H. pylori infection is likely a surrogate for poor hygiene and not an important source of antigens involved in the hygiene hypothesis. Helicobacter pylori in Malays is related to transmission from H. pylori-infected non-Malay immigrants. The factors responsible for low H. pylori acquisition, transmission, and burden of H. pylori infection in Malays remain unclear and likely involves a combination of environmental, host (gene polymorphisms), and strain virulence factors. Based on evidence from this population, absence of H. pylori infection is more likely to be boon than a bane.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.