ArticleClinical and experimental immunology2013
Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis.
Article in Clinical and experimental immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- The intricate relationship between autoimmunity disease and neutrophils death patterns: a love-hate story.Apoptosis : an international journal on programmed cell death · 2023Review
- The complement system and human autoimmune diseases.Journal of autoimmunity · 2023Review
- Overview on the Link Between the Complement System and Auto-Immune Articular and Pulmonary Disease.Open access rheumatology : research and reviews · 2023Review
- Complement System Inhibition Modulates the Inflammation Induced by the Venom ofInternational journal of molecular sciences · 2022Article
- Association of C1q gene cluster variants with rheumatoid arthritis: a pilot study.Rheumatology international · 2022Article
- Risk of C1q variation in systemic lupus erythematosus: a meta-analysis with Trial Sequential Analysis.Postepy dermatologii i alergologii · 2022Article
- The C1q-ApoE complex: A new hallmark pathology of viral hepatitis and nonalcoholic fatty liver disease.Frontiers in immunology · 2022Article
- Identification of Novel Targets of Knee Osteoarthritis Shared by Cartilage and Synovial Tissue.International journal of molecular sciences · 2020Article
- Complement and its environmental determinants in the progression of human rheumatoid arthritis.Molecular immunology · 2019Article
- Complement C1q expression in Erythema nodosum leprosum.PLoS neglected tropical diseases · 2018Article
- Is the A-Chain the Engine That Drives the Diversity of C1q Functions? Revisiting Its Unique Structure.Frontiers in immunology · 2018Article
- Proteinase 3 Interferes With C1q-Mediated Clearance of Apoptotic Cells.Frontiers in immunology · 2018Article
- Arthritis models: usefulness and interpretation.Seminars in immunopathology · 2017Review
- C1q as an autocrine and paracrine regulator of cellular functions.Molecular immunology · 2017Review
- SLE-associated risk factors affect DC function.Immunological reviews · 2016Review
- Fundamental role of C1q in autoimmunity and inflammation.Immunologic research · 2015Review
- C1q rs292001 polymorphism and C1q antibodies in juvenile lupus and their relation to lupus nephritis.Clinical and experimental immunology · 2015Article
- Variation in complement protein C1q is not a major contributor to cognitive impairment in Parkinson's disease.Neuroscience letters · 2015Article
- Autoimmunity in 2013.Clinical reviews in allergy & immunology · 2014Review
- Relative contribution of c1q and apoptotic cell-surface calreticulin to macrophage phagocytosis.Journal of innate immunity · 2014Article
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Authors and funding
17 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rodent models for arthritis implicate a role for complement in disease development and progression. In humans, complement deposition has been observed in inflamed synovia of rheumatoid arthritis (RA) patients. In this study we analysed whether genetic variants of complement component C1q predispose to RA. We genotyped single nucleotide polymorphisms (SNPs) in and around the C1q genes, C1qA, C1qB and C1qC, in a Dutch set of 845 RA cases and 1046 controls. Replication was sought in a sample set from North America (868 cases/1193 controls), and a meta-analysis was performed in a combined samples set of 8000 cases and 23 262 controls of European descent. We determined C1q serum levels in relation to C1q genotypes. In the discovery phase, five of the 13 SNPs tested in the C1q genes showed a significant association with RA. Additional analysis of the genomic area around the C1q genes revealed that the strongest associating SNPs were confined to the C1q locus. Within the C1q locus we observed no additional signal independent of the strongest associating SNP, rs292001 [odds ratio (OR) = 0·72 (0·58-0·88), P = 0·0006]. The variants of this SNP were associated with different C1q serum levels in healthy controls (P = 0·006). Interestingly, this SNP was also associated significantly in genome-wide association studies (GWAS) from the North American Rheumatoid Arthritis Consortium study, confirming the association with RA [OR = 0·83 (0·69-1·00), P = 0·043]. Combined analysis, including integrated data from six GWAS studies, provides support for the genetic association. Genetic variants in C1q are correlated with C1q levels and may be a risk for the development of RA.
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