Evidence map›Paper›PMID 23607419›Full record

ArticleClinical and experimental immunology2013

The effect of mesenchymal stem cells on dynamic changes of T cell subsets in experimental autoimmune uveoretinitis.

G Li, L Yuan, X Ren, H Nian, L Zhang, Z C Han, X Li, X Zhang

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03437759 (Mesenchymal Stem Cells Derived Exosomes Promote Healing of Large and Refractory Macular Holes), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03437759 early_phase1unknown statusnot on this mapstarted 2017, after this paper: background citation

Mesenchymal Stem Cells Derived Exosomes Promote Healing of Large and Refractory Macular Holes

TypeinterventionalSponsorTianjin Medical UniversityRan2017 to 2021Enrolled44ConditionsMacular HolesArmsexosomes derived from mesenchymal stem cells (MSC-Exo)
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Pooled it
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  12. Effects of mesenchymal stem cells and their exosomes on the healing of large and refractory macular holes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

G LiTianjin Medical University Eye Hospital and Eye Institute, Tianjin, China.
L Yuan
X Ren
H Nian
L Zhang
Z C Han
X Li
X Zhang
Tianjin Medical University · CNInstitute of Hematology & Blood Diseases Hospital · CNTianjin Medical University Eye Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) are being explored extensively as a promising treatment for autoimmune diseases. We have recently reported that MSCs could ameliorate experimental autoimmune uveoretinitis (EAU) in rats. In this study, we examined further the effects of MSCs on the dynamics of T cell subsets in both eye and spleen and their cytokine production during the course of EAU. We focused on when and where the MSCs had inhibitory effects on T helper type 1 (Th1) and Th17 cells and how long the inhibitory effect lasted, in order to provide more mechanistic evidence for MSCs on the treatment of uveitis. Compared to the control group, administration of MSCs decreased the production of Th1 and Th17 cytokines significantly, while the production of Th2 and regulatory T cell (T(reg)) cytokines [interleukin (IL)-10 and transforming growth factor (TGF)-β] was elevated during the entire course of EAU. Correspondingly, the dynamic levels of IL-17 in the aqueous humour (AqH) were reduced in MSC-treated rats. Moreover, the ratio of Th17/T(reg) cells in both spleen and eye was decreased. These results provide powerful evidence that MSCs can regulate negatively both Th1 and Th17 responses and restore the balance of Th17/T(regs) in the whole course of EAU, which is important for the regression of the disease.

Indexed as

Mesenchymal Stem Cell TransplantationAnimalsAqueous HumorLymphokinesMaleNervous System Autoimmune Disease, ExperimentalOrgan SpecificityRatsRats, Inbred LewRats, WistarRetinitisSpecific Pathogen-Free OrganismsSpleenTh17 CellsTh1 CellsTh2 CellsLymphokinesTransforming Growth Factor beta1

Identifiers

PMID23607419
PMCPMC3694532
OpenAlexW1548417333

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.