ArticleBioscience reports2013
Polysialic and colanic acids metabolism in Escherichia coli K92 is regulated by RcsA and RcsB.
Article in Bioscience reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Enterobacterial common antigen repeat-unit flippase WzxE is required forApplied and environmental microbiology · 2025Article
- Article
- The Rcs System Contributes to the Motility Defects of the Twin-Arginine Translocation System Mutant of Extraintestinal Pathogenic Escherichia coli.Journal of bacteriology · 2022Article
- Predatory Bacteria Select for Sustained Prey Diversity.Microorganisms · 2021Article
- Accelerated production of α2,8- and α2,9-linked polysialic acid in recombinantBiotechnology reports (Amsterdam, Netherlands) · 2020Article
- The Gene Encoding NAD-Dependent Epimerase/Dehydratase,Microorganisms · 2019Article
- Tannic and gallic acids alter redox-parameters of the medium and modulate biofilm formation.AIMS microbiology · 2019Article
- A Disulfide Bond in the Membrane Protein IgaA Is Essential for Repression of the RcsCDB System.Frontiers in microbiology · 2017Article
- Transcriptional Responses of Escherichia coli to a Small-Molecule Inhibitor of LolCDE, an Essential Component of the Lipoprotein Transport Pathway.Journal of bacteriology · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have shown previously that Escherichia coli K92 produces two different capsular polymers known as CA (colanic acid) and PA (polysialic acid) in a thermoregulated manner. The complex Rcs phosphorelay is largely related to the regulation of CA synthesis. Through deletion of rscA and rscB genes, we show that the Rcs system is involved in the regulation of both CA and PA synthesis in E. coli K92. Deletion of either rcsA or rcsB genes resulted in decreased expression of cps (CA biosynthesis cluster) at 19°C and 37°C, but only CA production was reduced at 19°C. Concerning PA, both deletions enhanced its synthesis at 37°C, which does not correlate with the reduced kps (PA biosynthesis cluster) expression observed in the rcsB mutant. Under this condition, expression of the nan operon responsible for PA catabolism was greatly reduced. Although RcsA and RcsB acted as negative regulators of PA synthesis at 37°C, their absence did not reestablish PA expression at low temperatures, despite the deletion of rcsB resulting in enhanced kps expression. Finally, our results revealed that RcsB controlled the expression of several genes (dsrA, rfaH, h-ns and slyA) involved in the thermoregulation of CA and PA synthesis, indicating that RcsB is part of a complex regulatory mechanism governing the surface appearance in E. coli.
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