ArticleBioMed research international2013
Treatment of nonhealing diabetic lower extremity ulcers with skin graft and autologous platelet gel: a case series.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 57 citations in OpenAlex.
- Treatment of chronic non-healing ulcers using autologous platelet rich plasma: a case series.Journal of biomedical science · 2017Trial
- Efficacy and safety of autologous platelet rich plasma for the treatment of vascular ulcers in primary care: Phase III study.BMC family practice · 2014Trial
- Platelet-rich plasma in the management of diabetic foot ulcers (Review).Biomedical reports · 2026Review
- Shenhuang Liuwei Powder Alleviates Streptozotocin-Induced Diabetic Ulcers in Rats through the Inhibition of the AGE/RAGE Signaling Pathway and Promotion of Antibacterial Activity and Angiogenesis via Activation of the PI3K/Akt/eNOS/HIF-1α Pathway.Combinatorial chemistry & high throughput screening · 2026Article
- Platelet-Rich Plasma for Wound Healing in Diabetic Patients.Medicina (Kaunas, Lithuania) · 2025Review
- Amplification of Wound Healing by Propolis and Honey Ointment in Healthy and Diabetic Rat Models; Histopathological and Morphometric Findings.Archives of Razi Institute · 2022Article
- Effectiveness of Injected Platelet-Rich Plasma in the Treatment of Diabetic Foot Ulcer Disease.Cureus · 2022Article
- Article
- Application of a simple skin stretching system and negative pressure wound therapy in repair of complex diabetic foot wounds.Journal of orthopaedic surgery and research · 2021Article
- Closure of a Difficult-to-Manage Chronic Pressure Injury with the Use of Autologous Platelet-Rich Plasma (APRP).International medical case reports journal · 2021Article
- Efficacy and Safety of Platelet-Rich Plasma for Patients with Diabetic Ulcers: A Systematic Review and Meta-analysis.Advances in wound care · 2019Review
- Efficacy of Autologous Platelet-Rich Gel for Diabetic Foot Wound Healing: A Meta-Analysis of 15 Randomized Controlled Trials.Advances in wound care · 2019Article
- [New progress in the treatment of chronic wound of diabetic foot].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018Article
- Stromal Cell-Derived Factor-1BioMed research international · 2018Article
- Treatment of a Refractory Skin Ulcer Using Punch Graft and Autologous Platelet-Rich Plasma.Case reports in dermatological medicine · 2016Article
- Platelet-rich plasma (PRP) promotes fetal mesenchymal stem/stromal cell migration and wound healing process.Stem cell reviews and reports · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lower extremity ulcers in diabetic patients are difficult to treat. Recently, the use of human blood platelet-derived components in this indication has been raising interest. In this study, we have evaluated the safety and efficacy of the combination of autologous platelet gel (PG) and skin graft for treating large size recalcitrant ulcers. Eight consecutive diabetic patients aged 25 to 82 with nine nonhealing lower extremity ulcers (median size of 50 cm(2); range 15-150 cm(2)) were treated. Skin ulcer was debrided, and the wound was sprayed after 7 to 10 days with autologous platelet-rich plasma and thrombin. Thin split-thickness skin graft with multiple slits was then applied on the wound bed and fixed with staples or cat-gut sutures. There were no adverse reactions observed during the study. Eight out of 9 skin grafts took well. The interval between skin graft and complete wound healing ranged from 2 to 3 weeks in the 8 successful cases. No ulcer recurrence was noted in those patients during the follow-up period of 2 to 19 months. In this study, the combination of autologous platelet gel and skin grafting has proven beneficial to heal large-size recalcitrant ulcers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.