ReviewClinical & developmental immunology2013
The immunologic basis for severe neonatal herpes disease and potential strategies for therapeutic intervention.
Review in Clinical & developmental immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- The immunogenetic basis of severe herpes simplex infections in neonates and children: a review.Pediatric research · 2025Review
- Age-dependent differences in type I interferon, IL-12 and pro-inflammatory cytokine production by porcine peripheral blood mononuclear cells in response to pseudorabies virus-infected cells.Frontiers in immunology · 2025Article
- Proteomic profiling of neonatal herpes simplex virus infection on dried blood spots.Communications medicine · 2024Article
- Neonatal herpes: case series in two obstetric centres over a 10-year period (2013-2023), France.European journal of pediatrics · 2024Article
- Lifetime quality-adjusted life years lost due to genital herpes acquired in the United States in 2018: a mathematical modeling study.Lancet regional health. Americas · 2023Article
- Multi-phenotype analysis for enhanced classification of 11 herpes simplex virus 1 strains.The Journal of general virology · 2022Article
- Inborn Errors of Immunity in the Premature Infant: Challenges in Recognition and Diagnosis.Frontiers in immunology · 2021Review
- Article
- Vaccines for Perinatal and Congenital Infections-How Close Are We?Frontiers in pediatrics · 2020Review
- Laboratory Diagnosis of Neonatal Herpes Simplex Virus Infections.Journal of clinical microbiology · 2019Review
- Enhanced expression of IFI16 and RIG-I in human third-trimester placentas following HSV-1 infection.Clinical and experimental immunology · 2018Article
- Virus and host-specific differences in oral human herpesvirus shedding kinetics among Ugandan women and children.Scientific reports · 2017Article
- First estimates of the global and regional incidence of neonatal herpes infection.The Lancet. Global health · 2017Article
- Plasma and cerebrospinal fluid herpes simplex virus levels at diagnosis and outcome of neonatal infection.The Journal of pediatrics · 2015Article
- Differential reliance on autophagy for protection from HSV encephalitis between newborns and adults.PLoS pathogens · 2015Article
- Herpes simplex virus serotype and entry receptor availability alter CNS disease in a mouse model of neonatal HSV.Pediatric research · 2014Article
- Prospects and perspectives for development of a vaccine against herpes simplex virus infections.Expert review of vaccines · 2014Review
- Is Infant Immunity Actively Suppressed or Immature?Virology : research and treatment · 2014Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2) infect a large proportion of the world's population. Infection is life-long and can cause periodic mucocutaneous symptoms, but it only rarely causes life-threatening disease among immunocompetent children and adults. However, when HSV infection occurs during the neonatal period, viral replication is poorly controlled and a large proportion of infants die or develop disability even with optimal antiviral therapy. Increasingly, specific differences are being elucidated between the immune system of newborns and those of older children and adults, which predispose to severe infections and reflect the transition from fetal to postnatal life. Studies in healthy individuals of different ages, individuals with primary or acquired immunodeficiencies, and animal models have contributed to our understanding of the mechanisms that control HSV infection and how these may be impaired during the neonatal period. This paper outlines our current understanding of innate and adaptive immunity to HSV infection, immunologic differences in early infancy that may account for the manifestations of neonatal HSV infection, and the potential of interventions to augment neonatal immune protection against HSV disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.