ArticleNMR in biomedicine2013
MRI confirms loss of blood-brain barrier integrity in a mouse model of disseminated candidiasis.
Article in NMR in biomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Tau is necessary for Pseudomonas aeruginosa-induced blood-brain barrier dysfunction.Communications biology · 2026Article
- Unraveling brain aging through the lens of oral microbiota.Neural regeneration research · 2025Article
- The FVirulence · 2023Article
- A novel report on the emerging and zoonotic neurotropic fungus Trichosporon japonicum in the brain tissue of the endangered Brazilian guitarfish (Pseudobatos horkelii) off the southeastern coast of Brazil.BMC microbiology · 2023Article
- Host immune responses in the central nervous system during fungal infections.Immunological reviews · 2022Review
- Research progress on the relationship between chronic periodontitis and Parkinson's disease.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2022Review
- CouldJournal of clinical medicine · 2022Review
- It's all in your head: antifungal immunity in the brain.Current opinion in microbiology · 2020Review
- Redundant Trojan horse and endothelial-circulatory mechanisms for host-mediated spread of Candida albicans yeast.PLoS pathogens · 2020Article
- Let's shine a light on fungal infections: A noninvasive imaging toolbox.PLoS pathogens · 2020Review
- Endothelial nitric oxide synthase limits host immunity to control disseminated Candida albicans infections in mice.PloS one · 2019Article
- MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Bridging barriers: a comparative look at the blood-brain barrier across organisms.Genes & development · 2018Review
- Utilization of MRI for Cerebral White Matter Injury in a Hypobaric Swine Model-Validation of Technique.Military medicine · 2017Article
- Neuroinflammation and structural injury of the fetal ovine brain following intra-amniotic Candida albicans exposure.Journal of neuroinflammation · 2016Article
- Inhibiting the immunoproteasome exacerbates the pathogenesis of systemic Candida albicans infection in mice.Scientific reports · 2016Article
- Article
- Fungal Infection in the Brain: What We Learned from Intravital Imaging.Frontiers in immunology · 2016Review
- Imaging Candida Infections in the Host.Methods in molecular biology (Clifton, N.J.) · 2016Article
- Experimental autoimmune encephalomyelitis development is aggravated by Candida albicans infection.Journal of immunology research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Disseminated candidiasis primarily targets the kidneys and brain in mice and humans. Damage to these critical organs leads to the high mortality associated with such infections, and invasion across the blood-brain barrier can result in fungal meningoencephalitis. Candida albicans can penetrate a brain endothelial cell barrier in vitro through transcellular migration, but this mechanism has not been confirmed in vivo. MRI using the extracellular vascular contrast agent gadolinium diethylenetriaminepentaacetic acid demonstrated that integrity of the blood-brain barrier is lost during C. albicans invasion. Intravital two-photon laser scanning microscopy was used to provide the first real-time demonstration of C. albicans colonizing the living brain, where both yeast and filamentous forms of the pathogen were found. Furthermore, we adapted a previously described method utilizing MRI to monitor inflammatory cell recruitment into infected tissues in mice. Macrophages and other phagocytes were visualized in kidney and brain by the administration of ultrasmall iron oxide particles. In addition to obtaining new insights into the passage of C. albicans across the brain microvasculature, these imaging methods provide useful tools to study further the pathogenesis of C. albicans infections, to define the roles of Candida virulence genes in kidney versus brain infection and to assess new therapeutic measures for drug development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.