ArticleThe AAPS journal2013
Predictive models of diffusive nanoparticle transport in 3-dimensional tumor cell spheroids.
Article in The AAPS journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- New approach methodologies in nanomedicine: bridging the gap betweenChemical Society reviews · 2026Review
- siRNA Delivery via Cross-Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic-Vascular Cross-Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA.Advanced healthcare materials · 2026Article
- Lipid-Polymer Nanoparticles (LiPoNs) Mediated Codelivery of AntimiR-21 and Gadolinium Chelate in Triple Negative Breast Cancer Theranostics.Bioengineering (Basel, Switzerland) · 2026Article
- Long axial range 3D single-particle tracking using birefringent substrates.Nature communications · 2025Article
- Tumor Spheroid Uptake of Fluorescent Nanodiamonds Is Limited by Mass Density: A 4D Light-Sheet Assay.Chemical & biomedical imaging · 2025Article
- Finite Element Simulation of Interstitial-Lymphatic Fluid Flow and Nanodrug Transport in a Solid Tumor: An Intratumoral Injection Approach.BME frontiers · 2025Article
- Quantifying Imaging Agent Binding and Dissociation in 3-D Cancer Spheroid Tissue Culture Using Paired-Agent Principles.Annals of biomedical engineering · 2024Article
- Comparison of Tumour-Specific Phenotypes in Human Primary and Expandable Pancreatic Cancer Cell Lines.International journal of molecular sciences · 2023Article
- Chirality-enhanced transport and drug delivery of graphene nanocarriers to tumor-like cellular spheroid.Frontiers in chemistry · 2023Article
- Dark-Field Microscopic Study of Cellular Uptake of Carbon Nanodots: Nuclear Penetrability.Molecules (Basel, Switzerland) · 2022Article
- A Bayesian approach to estimate the diffusion coefficient of Rhodamine 6G in breast cancer spheroids.Journal of controlled release : official journal of the Controlled Release Society · 2021Article
- Semiconducting polymer nanoparticles for photothermal ablation of colorectal cancer organoids.Scientific reports · 2021Article
- Kinetics of Nanomedicine in Tumor Spheroid as anFrontiers in bioengineering and biotechnology · 2021Review
- 3D Tumor Spheroid Models for In Vitro Therapeutic Screening of Nanoparticles.Advances in experimental medicine and biology · 2021Article
- Multiscale modelling of drug transport and metabolism in liver spheroids.Interface focus · 2020Article
- Modeling of Nanotherapy Response as a Function of the Tumor Microenvironment: Focus on Liver Metastasis.Frontiers in bioengineering and biotechnology · 2020Review
- Improving nanotherapy delivery and action through image-guided systems pharmacology.Theranostics · 2020Review
- Pharmacokinetic/Pharmacodynamics Modeling of Drug-Loaded PLGA Nanoparticles Targeting Heterogeneously Vascularized Tumor Tissue.Pharmaceutical research · 2019Article
- Morphophenotypic classification of tumor organoids as an indicator of drug exposure and penetration potential.PLoS computational biology · 2019Article
- Target Site Delivery and Residence of Nanomedicines: Application of Quantitative Systems Pharmacology.Pharmacological reviews · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The rapidly evolving nanotechnology field highlights the need of better understanding the relationship between nanoparticle (NP) properties and NP transport in solid tumors. The present study tested the hypothesis that the diffusive transport and spatial distribution of NP can be predicted based on the following parameters: interstitial NP diffusivity, NP-cell interaction parameters (cell surface binding capacity, rate constants of association, dissociation, and internalization). We (a) established the models and equations; (b) experimentally measured, in monolayer pharynx FaDu cells, the model parameters for three NP formulations (negatively charged polystyrene beads, near-neutral liposomes, and positively charged liposomes, with respective diameter of 20, 110, and 130 nm); and (c) used the models and parameters to simulate NP diffusion in 3-dimensional (3D) systems. We next measured the NP concentration-depth profiles in tumor cell spheroids, an avascular 3D system, and found good agreement between model-simulated and experimental data in spheroids for the negative and neutral NP (>90% predicted data points at three NP concentrations and three treatment times were within the 95% confidence intervals of experimental data). Model performance was inferior for positive liposomes containing a fusogenic lipid. The present study demonstrated the possibility of using in vitro NP-cell biointerface data in monolayer cultures with in silico studies to predict the NP diffusive transport and concentration-time-depth profiles in 3D systems, as functions of NP concentrations and treatment times. Extending this approach to include convective transport may yield a cost-effective means to predict the NP delivery and residence in solid tumors.
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