Trial reportPediatric nephrology (Berlin, Germany)2013
Prednisone in the treatment of tubulointerstitial nephritis in children.
Trial report in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- IL-10 polymorphisms +434T/C, +504G/T, and -2849C/T may predispose to tubulointersititial nephritis and uveitis in pediatric population.PloS one · 2019Trial
- Tubulointerstitial nephritis and uveitis syndrome in children: What to keep an eye on.Acta ophthalmologica · 2026Article
- Acute tubulointerstitial nephritis after the second dose of the Pfizer COVID-19 vaccine.Clinical and experimental vaccine research · 2025Article
- Tubulointerstitial nephritis in children and adolescents.Pediatric nephrology (Berlin, Germany) · 2025Review
- Drugs in treating paediatric acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2023Review
- Favorable course of leptospirosis and hantavirus-induced acute tubulointerstitial nephritis under corticosteroid treatment.Pediatric nephrology (Berlin, Germany) · 2023Article
- Diagnostic and Management Strategies of Tubulointerstitial Nephritis and Uveitis Syndrome (TINU): Current Perspectives.Clinical ophthalmology (Auckland, N.Z.) · 2023Review
- Long-term outcome of biopsy-proven idiopathic tubulointersitial nephritis with or without uveitis in children-a nationwide follow-up study.Pediatric nephrology (Berlin, Germany) · 2021Article
- Aetiology, course and treatment of acute tubulointerstitial nephritis in paediatric patients: a cross-sectional web-based survey.BMJ open · 2021Article
- A rare case of tubulointerstitial nephritis and uveitis (TINU) syndrome: Answers.Pediatric nephrology (Berlin, Germany) · 2020Article
- A riddle wrapped in an enigma: acute kidney injury in a girl with Crohn's disease: Answers.Pediatric nephrology (Berlin, Germany) · 2020Article
- Acute tubulointerstitial nephritis in children- a retrospective case series in a UK tertiary paediatric centre.BMC nephrology · 2020Article
- Tenascin-C expression in renal biopsies from patients with tubulointerstitial nephritis and its relation to disease activity and prognosis.International journal of clinical and experimental pathology · 2020Article
- [Interstitial nephritis].Der Internist · 2019Article
- The Invisible Threat of Non-steroidal Anti-inflammatory Drugs for Kidneys.Frontiers in pediatrics · 2019Article
- FOXP3Pediatric nephrology (Berlin, Germany) · 2018Article
- Severe Acute Kidney Injury and Multiple Organ Failure in a 17-Day-Old Newborn: When Pathology Makes the Difference.Canadian journal of kidney health and disease · 2018Article
- Tubulointerstitial nephritis and uveitis.Current opinion in ophthalmology · 2017Review
- Tubulointerstitial nephritis: diagnosis, treatment, and monitoring.Pediatric nephrology (Berlin, Germany) · 2017Review
- Corticosteroid therapy can be delayed but not omitted in idiopathic tubulointerstitial nephritis.Pediatric nephrology (Berlin, Germany) · 2014Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with tubulointerstitial nephritis (TIN) may develop permanent renal impairment. However, there are no prospective studies available on the treatment of TIN.
methodsThe effect of prednisone in the treatment of TIN was evaluated in a total of 17 patients who received prednisone or who were followed up without medication. The patient group was subdivided based on the initial plasma creatinine (PCr), below or above 150 μmol/l.
resultsAll prednisone-treated patients had normal plasma creatinine (PCr) after 1 month of treatment (median 59.1 [45-85] μmol/l) whereas only 50 % of patients in the non-treatment group had normal creatinine (median 81.0 [42-123] μmol/l) at the same time point (p = 0.025). During 6 months' follow-up, PCr decreased in all patient groups; however, it decreased significantly only in prednisone-treated patients with baseline PCr >150 μmol/l (p < 0.001). At the end of follow-up, no difference in PCr, glomerular filtration rate (GFR), or low molecular weight (LMW) proteinuria could be found between the study groups. A considerable number of patients in both groups had subnormal GFR and/or persistent LMW proteinuria at the 6-month follow-up visit. Eighty-two percent of the patients had uveitis.
conclusionsPrednisone speeds up the recovery from renal symptoms of TIN, especially in patients with severe nephritis. The renal function did not differ significantly between prednisone and control patients after 6 months' follow-up.
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