ArticleCerebellum (London, England)2013
Gain control of synaptic response function in cerebellar nuclear neurons by a calcium-activated potassium conductance.
Article in Cerebellum (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Response Dynamics in an Olivocerebellar Spiking Neural Network With Non-linear Neuron Properties.Frontiers in computational neuroscience · 2019Article
- Robust transmission of rate coding in the inhibitory Purkinje cell to cerebellar nuclei pathway in awake mice.PLoS computational biology · 2017Article
- Synchronicity and Rhythmicity of Purkinje Cell Firing during Generalized Spike-and-Wave Discharges in a Natural Mouse Model of Absence Epilepsy.Frontiers in cellular neuroscience · 2017Article
- Developmental change in the contribution of voltage-gated Ca(2+) channels to the pacemaking of deep cerebellar nuclei neurons.Neuroscience · 2016Article
- Determinants of rebound burst responses in rat cerebellar nuclear neurons to physiological stimuli.The Journal of physiology · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Small conductance Ca(2+)-activated potassium (SK) current provides an important modulator of excitatory synaptic transmission, which undergoes plastic regulation via multiple mechanisms. We examined whether inhibitory input processing is also dependent on SK current in the cerebellar nuclei (CN) where inhibition provides the only route of information transfer from the cerebellar cortical Purkinje cells. We employed dynamic clamping in conjunction with computer simulations to address this question. We found that SK current plays a critical role in the inhibitory synaptic control of spiking output. Specifically, regulation of SK current density resulted in a gain control of spiking output, such that low SK current promoted large output signaling for large inhibitory cell input fluctuations due to Purkinje cell synchronization. In contrast, smaller nonsynchronized Purkinje cell input fluctuations were not amplified. Regulation of SK density in the CN therefore would likely lead to important consequences for the transmission of synchronized Purkinje cell activity to the motor system.
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Registered trials
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