ReviewJournal of mammary gland biology and neoplasia2013
Mammary stroma in development and carcinogenesis.
Review in Journal of mammary gland biology and neoplasia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Developing Mammary Gland Models for Biomedical Applications.Research (Washington, D.C.) · 2026Review
- The end of the genetic paradigm of cancer.PLoS biology · 2025Review
- Hormonal regulation of miRNA during mammary gland development.Biology open · 2024Article
- Mesenchyme instructs growth while epithelium directs branching in the mouse mammary gland.eLife · 2024Article
- Kindlin-2 in myoepithelium controls luminal progenitor commitment to alveoli in mouse mammary gland.Cell death & disease · 2023Article
- Fate decisions of breast cancer stem cells in cancer progression.Frontiers in oncology · 2022Review
- ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism.Nature cell biology · 2020Article
- Exosomal microRNA communication between tissues during organogenesis.RNA biology · 2017Review
- Tissue specific microenvironments: a key tool for tissue engineering and regenerative medicine.Journal of biological engineering · 2017Review
- Relationship between histology, development and tumorigenesis of mammary gland in female rat.Experimental animals · 2016Review
- In-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk loci.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Loss of vitamin D receptor signaling from the mammary epithelium or adipose tissue alters pubertal glandular development.American journal of physiology. Endocrinology and metabolism · 2014Article
- A potential mechanism for extracellular matrix induction of breast cancer cell normality.Breast cancer research : BCR · 2014Article
- Prenatal morphogenesis of mammary glands in mouse and rabbit.Journal of mammary gland biology and neoplasia · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammary glands of adult human females are secretory organs comprised of interdependent epithelial and mesenchymal cells. These cells constitute an assemblage of collecting ducts that end in terminal duct lobular units with hollow alveolar ductules that can differentiate to produce and expel milk. Systemic and maternal hormones, autocrine and paracrine growth factors, and cytokines regulate virtually all phases of mammary gland development. During organogenesis, epithelial and mesenchymal cells interact to form precursors of the parenchyma and stroma in the mature gland. Organogenesis precedes five stages of postnatal development: puberty, pregnancy, lactation, involution, and menopause. Each stage requires a specific set of morphogenetic changes in glandular structure and function. Cycles of cell proliferation, differentiation, and involution may recur until menopause. In addition, physiological responses such as inflammation and pathological events such as tumorigenesis are remarkable for their similarities to embryonic morphogenesis. Here we take a succinct look at the ever-improving understanding of stroma-epithelial interactions and mesenchyme function in mammary gland biology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.