ArticleJournal of the American Aging Association2001
Role of xanthine dehydrogenase and aging on the innate immune response of Drosophila.
Article in Journal of the American Aging Association, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Worker Survival and Egg Production-But Not Transcriptional Activity-Respond to Queen Number in the Highly Polygynous, Invasive Ant Tapinoma magnum.Molecular ecology · 2025Article
- Research on the Expression of Immune-Related Genes at Different Stages in the Third-Instar Larvae ofInsects · 2025Article
- Mutational disparities in colorectal cancers of White Americans, Alabama African Americans, And Oklahoma American Indians.NPJ precision oncology · 2024Article
- Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system.Nature aging · 2024Article
- Immune system modulation & virus transmission during parasitism identified by multi-species transcriptomics of a declining insect biocontrol system.BMC genomics · 2024Article
- Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L.Scientific reports · 2022Article
- Exogenous application of xanthine and uric acid and nucleobase-ascorbate transporter MdNAT7 expression regulate salinity tolerance in apple.BMC plant biology · 2021Article
- The Resistance ofAntioxidants (Basel, Switzerland) · 2020Article
- Bioinformatic prediction of critical genes and pathways involved in longevity in Drosophila melanogaster.Molecular genetics and genomics : MGG · 2019Article
- Unraveling the Molecular Mechanism of Immunosenescence inInternational journal of molecular sciences · 2018Review
- Characterization of xanthine dehydrogenase and aldehyde oxidase of Marsupenaeus japonicus and their response to microbial pathogen.Molecular biology reports · 2018Article
- Longevity extension in Drosophila through gut-brain communication.Scientific reports · 2018Article
- Dual and Opposing Roles of Xanthine Dehydrogenase in Defense-Associated Reactive Oxygen Species Metabolism in Arabidopsis.The Plant cell · 2016Article
- Pleiotropy and life history evolution in Drosophila melanogaster: uncoupling life span and early fecundity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- Molecular mechanisms of aging and immune system regulation in Drosophila.International journal of molecular sciences · 2012Review
- Gene silencing in phlebotomine sand flies: Xanthine dehydrogenase knock down by dsRNA microinjections.Insect biochemistry and molecular biology · 2008Article
- Drosophila lifespan enhancement by exogenous bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been proposed that uric acid is an important scavenger of deleterious oxygen species and peroxynitrite in biological systems. The cellular sources responsible for the generation of damage-causing reactive oxygen species (ROS) are widespread. Xanthine dehydrogenase (XDH) / oxidase (XOD) catalyzes the oxidation of xanthine to uric acid. The rosy (ry) gene encodes XDH/XOD in Drosophila melanogaster. XDH codes for uric acid which is a ROS scavenger. XOD however is an enzyme system implicated in ROS production. In this study, we investigated the roles of XDH in the fly's immune defense response to infection and in the aging process. We first compared ROS generation and nitric oxide (NO) level in the whole body and the gut of XDH mutant with those of wild type. Our results suggested that XDH has a protective effect with respect to both ROS and NO generations, particularly in the gut. We also examined the effect of a XDH deletion mutant on the relative sensitivity of the organism against bacterial infection, on the immune inducibility of antimicrobial peptides and on the effect of aging in the defensive response to infection. Our results strongly suggest that XDH plays an important role in the innate immune response and that the age-associated deterioration of the innate immune response might be, at least in part, associated with the loss of XDH activity in the aging process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.