ArticleClinical oral investigations2013
Herpes simplex virus reactivation and dental procedures.
Article in Clinical oral investigations, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- Herpesviruses: overview of systematics, genomic complexity and life cycle.Virology journal · 2025Review
- Plant Cell-Engineered Gold Nanoparticles Conjugated to Quercetin Inhibit SARS-CoV-2 and HSV-1 Entry.International journal of molecular sciences · 2023Article
- Review
- Vaccines against Genital Herpes: Where Are We?Vaccines · 2020Review
- Strength in diversity: Understanding the pathways to herpes simplex virus reactivation.Virology · 2018Review
- Rare Occurrence of Herpes Zoster of Trigeminal Nerve following Extraction of Tooth.Case reports in dentistry · 2015Article
- Detection of herpesvirus EBV DNA in the lower respiratory tract of ICU patients: a marker of infection of the lower respiratory tract?Medical microbiology and immunology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesDental extraction is reported to trigger recurrent herpes labialis (RHL).
aimThis aims to prospectively study the clinical occurrence of RHL and the oral herpes simplex virus type 1 (HSV-1) viral shedding before and 3 days after different dental procedures. MATERIALS AND
methodsOral HSV-1 DNA was measured by real-time PCR before and 3 days after dental procedures of the inferior dentition in 57 immunocompetent patients (mean age 32.4 years) who were selected and divided into four distinct subgroups (dental inspection without anesthesia, n = 19; dental filling under local anesthesia, n = 14; molar extraction under local anesthesia, n = 15; and molar extraction under general anesthesia, n = 9) and compared to 32 healthy controls (mean age 33 years).
resultsNone of the patients suffered from RHL at day 3. Oral HSV-1 DNA was detected before and after procedure in 1.7 % (1/57) and 5.3 % (3/57), respectively [dental inspection without anesthesia, 5.3 % (1/19); molar extraction under local anesthesia, 6.7 % (1/15); and molar extraction under general anesthesia, 11 % (1/9)]. None of the controls presented RHL or detectable oral HSV-1 DNA. There was no statistically significant difference between the study groups and controls.
conclusionMolar extraction increases the risk of oral HSV-1 shedding but not of RHL. Procedure-related nerve damage probably accounts for HSV reactivation. CLINICAL RELEVANCE: Antiviral prophylaxis for RHL is not routinely recommended for dental procedures, regardless of a prior history of RHL.
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