ArticleLipids2013
Regioisomers of phosphatidylcholine containing DHA and their potential to deliver DHA to the brain: role of phospholipase specificities.
Article in Lipids, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Omega-3 Fatty Acids and Neurodegenerative Diseases: New Evidence in Clinical Trials.International journal of molecular sciences · 2019Pooled it
- Flaxseed feeding enriches plasmalogens and glycosphingolipids and alters the esterification site of PUFAs in egg yolk phospholipids based on lipidomics analysis.Food chemistry: X · 2026Article
- Compound-Specific Isotope Analysis as a Potential Approach for Investigation of Cerebral Accumulation of Docosahexaenoic Acid: Previous Milestones and Recent Trends.Molecular neurobiology · 2025Review
- Effects of APOE4 on omega-3 brain metabolism across the lifespan.Trends in endocrinology and metabolism: TEM · 2024Review
- Why Have the Benefits of DHA Not Been Borne Out in the Treatment and Prevention of Alzheimer's Disease? A Narrative Review Focused on DHA Metabolism and Adipose Tissue.International journal of molecular sciences · 2021Review
- Potential role of hepatic lipase in the accretion of docosahexaenoic acid (DHA) by the brain.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2021Article
- Different mechanisms for selective transport of fatty acids using a single class of lipoprotein inJournal of lipid research · 2019Article
- Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Review
- Developmental changes in polyunsaturated fetal plasma phospholipids and feto-maternal plasma phospholipid ratios and their association with bronchopulmonary dysplasia.European journal of nutrition · 2016Article
- Role of docosahexaenoic acid in the modulation of glial cells in Alzheimer's disease.Journal of neuroinflammation · 2016Review
- Docosahexaenoic Acid and Cognition throughout the Lifespan.Nutrients · 2016Review
- Plasma phospholipids indicate impaired fatty acid homeostasis in preterm infants.European journal of nutrition · 2014Article
- Characterization of acyl chain position in unsaturated phosphatidylcholines using differential mobility-mass spectrometry.Journal of lipid research · 2014Article
- Environmental endocrine disruption of energy metabolism and cardiovascular risk.Current diabetes reports · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Because neurons cannot synthesize docosahexaenoic acid (DHA), a dietary supplement of DHA in the form of phospholipids is recommended for maintaining proper brain functions. A model for delivering dietary sn-2-DHA phosphatidylcholine (PtdCho) to the brain involves phospholipase A2 based deacylation/reacylation cycle followed by delivery of DHA through high-density lipoproteins that bind to the brain capillary endothelial cells in the blood-brain barrier (BBB). Our previous study demonstrated preference of endothelial lipase (EL) for PtdCho species that contain sn-2-DHA, resulting in production of sn-2-DHA lysoPtdCho that is preferentially taken up by the brain. However, since CoA-dependent reacylation of lysoPtdCho with DHA at the sn-2 position is not favored in vivo, we proposed that sn-1-DHA PtdCho in the diet may be a superior source of DHA for the brain. To test this hypothesis, DHA PtdCho regioisomers were prepared, and their hydrolysis by physiologically relevant phospholipases was determined. The data presented here show that: (1) group X secretory PLA2 (sPLA2) is about threefold more active than group V sPLA2 in releasing sn-2 fatty acids from DHA regioisomers, and (2) EL shows its specificity for DHA PtdCho species in a concentration independent manner, suggesting that the enzyme could play a major role in generating free sn-1-DHA or/and sn-2-DHA lysoPtdCho from the regioisomers in the BBB. We propose that PtdCho species containing sn-1-DHA may have the advantages of both "preserving" DHA in deacylation/reacylation cycle and releasing free DHA in the BBB for uptake by the brain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.