ArticleClinical orthopaedics and related research2014
Healing delayed but generally reliable after bisphosphonate-associated complete femur fractures treated with IM nails.
Article in Clinical orthopaedics and related research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 4 of them syntheses that pooled it.
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Who cites it
63 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Early bisphosphonate therapy post proximal femoral fracture fixation does not impact fracture healing: a systematic review and meta-analysis.ANZ journal of surgery · 2022Pooled it
- Epidemiology and Postoperative Outcomes of Atypical Femoral Fractures in Older Adults: A Systematic Review.The journal of nutrition, health & aging · 2017Pooled it
- Delayed healing of lower limb fractures with bisphosphonate therapy.Annals of the Royal College of Surgeons of England · 2015Pooled it
- Bisphosphonates and their influence on fracture healing: a systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Pooled it
- Demineralized Bone Matrix Add-On for Acceleration of Bone Healing in Atypical Subtrochanteric Femoral Fracture: A Consecutive Case-Control Study.BioMed research international · 2016Trial
- Reconstruction with megaprosthesis for recurrent nonunion of an atypical periprosthetic femoral fracture in an elderly patient.Journal of surgical case reports · 2026Article
- Magnesium-containing implants enhance bone healing: A mechanobiological perspective.Mechanobiology in medicine · 2025Review
- Development and validation of a nomogram model for predicting postoperative nonunion in femoral shaft fractures.BMC musculoskeletal disorders · 2025Article
- Differences Between Atypical and Typical Subtrochanteric Fractures Due to Low-Energy Trauma.Cureus · 2025Article
- Well-reduced bisphosphonate-associated atypical femur fractures have low rates of nonunion and delayed union.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- PDGF-BB improves cortical bone quality through restoring the osteogenic microenvironment in the steroid-associated osteonecrosis of rabbits.Journal of orthopaedic translation · 2025Article
- Management Concepts of Bisphosphonate-Related Atypical Femoral Fractures.Journal of clinical medicine · 2025Article
- Use of medialized trochanteric-entry intramedullary nail to improve alignment in proximal femur nonunions.International orthopaedics · 2025Article
- A Displaced Atypical Femoral Fracture Healed Without Anti-osteoporotic Agents in a Case of Ankylosing Spondylitis.Cureus · 2024Article
- The effect of valgus reduction on resistant subtrochanteric femoral non-unions: a single-centre report of twenty six cases.International orthopaedics · 2024Article
- Bisphosphonate-Related Atypical Femoral Fractures in Patients with Autoimmune Disease Treated with Glucocorticoids: Surgical Results for 20 Limbs.Journal of clinical medicine · 2024Article
- Factors Affecting the Second Complete Atypical Femoral Fracture after the First Atypical Fracture.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024Article
- Article
- Plate Fixation for Atypical Fractures of the Femoral Diaphysis.Clinics in orthopedic surgery · 2022Article
- Bilateral atypical femoral fractures treated with compression hip screw and intramedullary nail fixation.Trauma case reports · 2022Article
3 more citing papers are in PubMed but not listed here.
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundBisphosphonate therapy for osteoporosis has been associated with atypical femoral fractures. To date, there have been few reports in the literature regarding the preoperative and postoperative courses of patients who have sustained bisphosphonate-associated complete atypical femur fractures. OBJECTIVES/PURPOSES: The purposes of this study were to (1) characterize the preoperative course of patients who eventually presented with bisphosphonate-associated complete atypical femur fractures (duration of bisphosphonate treatment, pain history, risk of converting a nondisplaced fracture to a complete fracture); (2) evaluate the percentage of patients who achieved radiographic union of those fractures after treatment; and (3) determine the patients' recovery of function using the Short Musculoskeletal Functional Assessment.
methodsThirty-three patients with 41 atypical, low-energy femur fractures associated with ≥ 5 years of bisphosphonate use were treated with intramedullary nailing between 2004 and 2011 at one center. The main outcome measurements were Short Musculoskeletal Functional Assessment for function and radiographic evaluation for fracture healing. Patients had been treated with bisphosphonates for an average of 8.8 years (range, 5-20 years) before presentation.
resultsPatients reported a mean of 6 months of pain before presentation (range, 1-8 months). Sixty-six percent of patients with surgically treated complete fractures became pain-free and 98% were radiographically healed by 12 months. Sixty-four percent of patients who underwent intramedullary nailing reported a functional return to baseline within 1 year. Patients who reported major functional limitations at latest followup listed pain and apprehension as the major causes of their limitation.
conclusionsPatients with surgically treated bisphosphonate-associated complete femur fractures achieved generally reliable although delayed fracture healing if malaligned, and nearly two-thirds of patients returned to self-reported baseline function within 1 year. LEVEL OF EVIDENCE: Level III, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
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