ArticleCurrent microbiology2013
Effects of age and strain on the microbiota colonization in an infant human flora-associated mouse model.
Article in Current microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Developing the Common Marmoset as a Translational Geroscience Model to Study the Microbiome and Healthy Aging.Microorganisms · 2024Review
- Gut microbiota absence and transplantation affect diarrhea: an investigation in the germ-free piglet model.Animal biotechnology · 2023Article
- Review
- Gut microbiota absence and transplantation affect growth and intestinal functions: An investigation in a germ-free pig model.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Article
- Lactobacillus plantarum BSGP201683 Improves the Intestinal Barrier of Giant Panda Microbiota-Associated Mouse Infected by Enterotoxigenic Escherichia coli K88.Probiotics and antimicrobial proteins · 2021Article
- Correlation of Breed, Growth Performance, and Rumen Microbiota in Two Rustic Cattle Breeds Reared Under Different Conditions.Frontiers in microbiology · 2021Article
- The Panda-DerivedFrontiers in immunology · 2021Article
- Exogenous Fecal Microbial Transplantation Alters Fearfulness, Intestinal Morphology, and Gut Microbiota in Broilers.Frontiers in veterinary science · 2021Article
- Effects of Early Transplantation of the Faecal Microbiota from Tibetan Pigs on the Gut Development of DSS-Challenged Piglets.BioMed research international · 2021Article
- Article
- Commensal Microbiota Regulation of Metabolic Networks During Olfactory Dysfunction in Mice.Neuropsychiatric disease and treatment · 2020Article
- Oral bacteria colonize and compete with gut microbiota in gnotobiotic mice.International journal of oral science · 2019Article
- Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke.Frontiers in neurology · 2019Article
- Ecological Balance of Oral Microbiota Is Required to Maintain Oral Mesenchymal Stem Cell Homeostasis.Stem cells (Dayton, Ohio) · 2018Article
- Modulation of intestine development by fecal microbiota transplantation in suckling pigs.RSC advances · 2018Article
- Early Gut Microbiota Intervention Suppresses DSS-Induced Inflammatory Responses by Deactivating TLR/NLR Signalling in Pigs.Scientific reports · 2017Article
- Microbiota composition of simultaneously colonized mice housed under either a gnotobiotic isolator or individually ventilated cage regime.Scientific reports · 2017Article
- Intestinal microbiota could transfer host Gut characteristics from pigs to mice.BMC microbiology · 2016Article
- Gut microbiota can transfer fiber characteristics and lipid metabolic profiles of skeletal muscle from pigs to germ-free mice.Scientific reports · 2016Article
- Microbiota Modulates Behavior and Protein Kinase C mediated cAMP response element-binding protein Signaling.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The establishment of human flora-associated animal models allows the in vivo manipulation of host, microbial, and environmental parameters to influence the gut microbial community. However, it is difficult to simulate infant gut microbiota in germ-free animals because of the variation and dynamic state of infant microbial communities. In this study, the effects of age and strain on intestinal microbiota were observed in an infant human flora-associated (IHFA) mouse model. To establish an IHFA model, postnatal day (PND) 1 germ-free mice (Kunming, n = 10; BALB/c, n = 10) were infected with feces from a breast-fed infant. Microbiota in the feces of BALB/c mice (at PND 7, 14, and 21), and Kunming mice (at PND 14) were analyzed by PCR-denaturing gradient gel electrophoresis. Bifidobacteria and lactobacilli levels in the feces of BALB/c and Kunming mice (PND 7/14/21) were detected by quantitative real-time PCR. The Dice similarity coefficient (Cs) for the fecal microbiota of IHFA mice in comparison with the HD donor sample was higher for BALB/c mice than for Kunming mice (P < 0.05). In addition, the DCs at PND 7 were lower than those at PND 14 and PND 21 in both mouse strains (P < 0.05). The Bifidobacteria and Lactobacillus species colonizing the BALB/c mice were similar to those in the Kunming mice (at PND 7/14/21). The bifidobacteria counts increased with age in both mouse strains, whereas the lactobacilli counts decreased with age in both strains. These results suggest that both age and strain influence microbiota patterns in the IHFA mouse model.
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