ArticleAge1998
Oxidative stress and superoxide dismutase in development, aging and gene regulation.
Article in Age, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- The Effects of Radiation Therapy on the Ocular Apparatus: Implications for Management.Cancers · 2025Review
- Role of oxidative stress in post-burn wound healing.Burns & trauma · 2025Review
- Integrated comparison of growth and oxidative stress induced by tylosin in two freshwater algae Chlorella vulgaris and Raphidocelis subcapitata.Ecotoxicology (London, England) · 2022Article
- Extracting protein from microalgae (MethodsX · 2022Article
- Positive Effect ofMolecules (Basel, Switzerland) · 2021Article
- Traumatic brain injury-induced cerebral microbleeds in the elderly.GeroScience · 2021Review
- Cosmetic and Dermatological Properties of Selected Ayurvedic Plant Extracts.Molecules (Basel, Switzerland) · 2021Article
- Effect of Fermentation Time on Antioxidant and Anti-Ageing Properties of Green Coffee Kombucha Ferments.Molecules (Basel, Switzerland) · 2020Article
- Association of PON1-L55M Genetic Variation and Breast Cancer Risk: A Case-Control Trial.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Csk-Induced Phosphorylation of Src at Tyrosine 530 is Essential for H2O2-Mediated Suppression of ERK1/2 in Human Umbilical Vein Endothelial Cells.Scientific reports · 2015Article
- Oxidative stress and genetic markers of suboptimal antioxidant defense in the aging brain: a theoretical review.Reviews in the neurosciences · 2014Review
- Effects of oxygen, growth state, and senescence on the antioxidant responses of WI-38 fibroblasts.Age (Dordrecht, Netherlands) · 2010Article
- Early onset senescence occurs when fibroblasts lack the glutamate-cysteine ligase modifier subunit.Free radical biology & medicine · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Free radicals and other reactive oxygen species are produced in the metabolic pathways of aerobic cells and affect a number of biological processes. Oxidation reactions have been postulated to play a role in aging, a number of degenerative diseases, differentiation and development as well as serving as subcellular messengers in gene regulatory and signal transduction pathways. The discovery of the activity of superoxide dismutase is a seminal work in free radical biology, because it established that free radicals were generated by cells and because it made removal of a specific free radical substance possible for the first time, which greatly accelerated research in this area. In this review, the role of reactive oxygen in aging, amyotrophic lateral sclerosis (a neurodegenerative disease), development, differentiation, and signal transduction are discussed. Emphasis is also given to the role of superoxide dismutases in these phenomena.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.