ReviewNutrients2013
Selenium supranutrition: are the potential benefits of chemoprevention outweighed by the promotion of diabetes and insulin resistance?
Review in Nutrients, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 6 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- The effect of selenium therapy in critically ill patients: an umbrella review of systematic reviews and meta-analysis of randomized controlled trials.European journal of medical research · 2023Pooled it
- Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis.European journal of epidemiology · 2018Pooled it
- Selenium for preventing cancer.The Cochrane database of systematic reviews · 2018Pooled it
- Association between serum selenium level and type 2 diabetes mellitus: a non-linear dose-response meta-analysis of observational studies.Nutrition journal · 2016Pooled it
- Genome-wide association study of selenium concentrations.Human molecular genetics · 2015Pooled it
- Selenium for preventing cancer.The Cochrane database of systematic reviews · 2014Pooled it
- Hydrogen selenide in biological systems: from synthetic donors to fluorescent probes.Chemical science · 2026Review
- A U-shaped association between blood selenium levels and prostate cancer: findings of a case-control study among Nigerian men.Scientific reports · 2025Article
- Serum selenium and reduced mortality in middle-aged and older adults with prefrailty or frailty: the mediating role of inflammatory status.Frontiers in nutrition · 2025Article
- Is Maternal Selenium Status Associated with Pregnancy Outcomes in Physiological and Complicated Pregnancy?Nutrients · 2024Article
- Understanding the Roles of Selenium on Thyroid Hormone-Induced Thermogenesis in Adipose Tissue.Biological trace element research · 2024Review
- Role of selenium in type 2 diabetes, insulin resistance and insulin secretion.World journal of diabetes · 2023Review
- The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies.Drug design, development and therapy · 2023Article
- Article
- A Comprehensive Review on the Processing of Dried Fish and the Associated Chemical and Nutritional Changes.Foods (Basel, Switzerland) · 2022Review
- Associations between Circulating SELENOP Level and Disorders of Glucose and Lipid Metabolism: A Meta-Analysis.Antioxidants (Basel, Switzerland) · 2022Review
- The role of selenium in type-2 diabetes mellitus and its metabolic comorbidities.Redox biology · 2022Review
- Factors Influencing Selenium Concentration in Community-Dwelling Patients with Type 2 Diabetes Mellitus.Biological trace element research · 2021Article
- Evaluation of Serum Selenium Status by Age and Gender: A Retrospective Observational Cohort Study in Western Romania.Nutrients · 2021Observational
- Toxicology and pharmacology of synthetic organoselenium compounds: an update.Archives of toxicology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selenium was considered a toxin until 1957, when this mineral was shown to be essential in the prevention of necrotic liver damage in rats. The hypothesis of selenium chemoprevention is principally formulated by the observations that cancer incidence is inversely associated with selenium status. However, recent clinical and epidemiological studies demonstrate a role for some selenoproteins in exacerbating or promoting other disease states, specifically type 2 diabetes, although other data support a role of selenium in stimulating insulin sensitivity. Therefore, it is clear that our understanding in the role of selenium in glucose metabolism and chemoprevention is inadequate and incomplete. Research exploring the role of selenium in individual healthcare is of upmost importance and possibly will help explain how selenium is a double-edged sword in the pathologies of chronic diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.