ArticleJournal of immunotherapy (Hagerstown, Md. : 1997)2013
Inhibition of lung metastasis by chemokine CCL17-mediated in vivo silencing of genes in CCR4+ Tregs.
Article in Journal of immunotherapy (Hagerstown, Md. : 1997), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- The immunomodulatory role of tumor-initiating cells in digestive system tumors: from mechanisms to therapy.Frontiers in immunology · 2025Review
- The Multifaceted Role of Regulatory T Cells in Breast Cancer.Annual review of cancer biology · 2021Article
- Sox2 Communicates with Tregs Through CCL1 to Promote the Stemness Property of Breast Cancer Cells.Stem cells (Dayton, Ohio) · 2017Article
- Current Progress in Non-viral RNAi-Based Delivery Strategies to Lymphocytes.Molecular therapy : the journal of the American Society of Gene Therapy · 2017Review
- Targeting metastasis.Nature reviews. Cancer · 2016Review
- Increased CCL17 serum levels are associated with improved survival in advanced melanoma.Cancer immunology, immunotherapy : CII · 2015Article
- Interleukin-5 facilitates lung metastasis by modulating the immune microenvironment.Cancer research · 2015Article
- Clinical significance of serum thymus and activation-regulated chemokine in gastric cancer: potential as a serum biomarker.Cancer science · 2014Article
- Expression of chemokine receptor 4 was associated with poor survival in renal cell carcinoma.Medical oncology (Northwood, London, England) · 2014Article
- Antisense therapeutics in oncology: current status.OncoTargets and therapy · 2014Review
- The role of chemoattractant receptors in shaping the tumor microenvironment.BioMed research international · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Despite significant attractiveness of antisense oligonucleotide/RNAi technology, its clinical application has been precluded by a lack of methods for targeted delivery and transduction of primary immune cells in vivo. Here, we devised a chemokine CCL17-based strategy (TARC-arp) that transiently silences expression of genes in immune cells by delivering inhibitory oligonucleotides through their chemokine receptors. In modeling studies using mice with established 4T1.2 breast cancer, we show that IL10 produced by CCR4 cells, in particular FoxP3 regulatory T cells (Tregs), plays an important role in lung metastasis. As such, TARC-arp-mediated silencing of IL10 or FoxP3 in CCR4 Tregs is sufficient to block lung metastasis. Thus, we provide a simple solution that circumvents the problems of RNAi use in vivo, indicating that a disease outcome can be successfully controlled by delivering inhibitory oligonucleotides with chemokines to inactivate a selective subset of immune cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.