Evidence map›Paper›PMID 23603846›Full record

ArticleDatabase : the journal of biological databases and curation2013

PhenoMiner: quantitative phenotype curation at the rat genome database.

Stanley J F Laulederkind, Weisong Liu, Jennifer R Smith, G Thomas Hayman, Shur-Jen Wang, Rajni Nigam, Victoria Petri, Timothy F Lowry, Jeff de Pons, Melinda R Dwinell and 1 more

Abstract read
In one paragraph

Article in Database : the journal of biological databases and curation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Mapping of EFO terms from the GWAS catalog data to multiple ontologies at the Rat Genome Database.Database : the journal of biological databases and curation · 2026
    Article
  3. Rat models of musculoskeletal lysosomal storage disorders and their role in pre-clinical evaluation of gene therapy approaches.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Review
  4. Establishing the hybrid rat diversity program: a resource for dissecting complex traits.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Integrated curation and data mining for disease and phenotype models at the Rat Genome Database.Database : the journal of biological databases and curation · 2019
    Article
  9. Chemical-Induced Phenotypes at CTD Help Inform the Predisease State and Construct Adverse Outcome Pathways.Toxicological sciences : an official journal of the Society of Toxicology · 2018
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. OntoMate: a text-mining tool aiding curation at the Rat Genome Database.Database : the journal of biological databases and curation · 2015
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stanley J F LaulederkindHuman and Molecular Genetics Center, Medical College of Wisconsin, Human and Molecular Genetics Center, 8701 Watertown Plank Rd, Milwaukee, WI 53226-3548, USA. slaulederkind@mcw.edu
Weisong Liu
Jennifer R Smith
G Thomas Hayman
Shur-Jen Wang
Rajni Nigam
Victoria Petri
Timothy F Lowry
Jeff de Pons
Melinda R Dwinell
Mary Shimoyama

Funding

RAT GENOME DATABASER01HL064541 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI ANNE E. KWITEK · 1999 to 2026
$50.0M
Integration of phenotype data from multiple centers using ontologiesR01HL094271 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI DWINELL, MELINDA R · 2010 to 2012
$1.1M
NHLBI NIH HHS HL064541NHLBI NIH HHS HL094271NHLBI NIH HHS HL64541NHLBI NIH HHS R01 HL064541
6 · The paper itself

Abstract

The Rat Genome Database (RGD) is the premier repository of rat genomic and genetic data and currently houses >40 000 rat gene records as well as human and mouse orthologs, >2000 rat and 1900 human quantitative trait loci (QTLs) records and >2900 rat strain records. Biological information curated for these data objects includes disease associations, phenotypes, pathways, molecular functions, biological processes and cellular components. Recently, a project was initiated at RGD to incorporate quantitative phenotype data for rat strains, in addition to the currently existing qualitative phenotype data for rat strains, QTLs and genes. A specialized curation tool was designed to generate manual annotations with up to six different ontologies/vocabularies used simultaneously to describe a single experimental value from the literature. Concurrently, three of those ontologies needed extensive addition of new terms to move the curation forward. The curation interface development, as well as ontology development, was an ongoing process during the early stages of the PhenoMiner curation project. Database URL: http://rgd.mcw.edu.

Indexed as

Databases, GeneticSoftwareAnimalsData MiningGenomeHumansMiceMolecular Sequence AnnotationPhenotypeRatsWorkflow

Identifiers

PMID23603846
PMCPMC3630803

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.