ArticleScientific reports2013
Dynamic modular architecture of protein-protein interaction networks beyond the dichotomy of 'date' and 'party' hubs.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identification of interconnected markers for T-cell acute lymphoblastic leukemia.BioMed research international · 2013Pooled it
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- Integration of Gastric Cancer RNA-Seq Datasets Along With PPI Network Suggests That Nonhub Nodes Have the Potential to Become Biomarkers.Cancer reports (Hoboken, N.J.) · 2025Article
- Protein-protein interaction (PPI) network analysis reveals important hub proteins and sub-network modules for root development in rice (Oryza sativa).Journal, genetic engineering & biotechnology · 2023Article
- Calculation of centralities in protein kinase A.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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- Specialization in plant-pollinator networks: insights from local-scale interactions in Glenbow Ranch Provincial Park in Alberta, Canada.BMC ecology · 2019Article
- Gene co-expression network analysis identifies trait-related modules in Arabidopsis thaliana.Planta · 2019Article
- Detecting sequences of system states in temporal networks.Scientific reports · 2019Article
- Article
- Hub Protein Controversy: Taking a Closer Look at Plant Stress Response Hubs.Frontiers in plant science · 2018Review
- Network Rewiring in Cancer: Applications to Melanoma Cell Lines and the Cancer Genome Atlas Patients.Frontiers in genetics · 2018Article
- Common and Rare Genetic Risk Factors Converge in Protein Interaction Networks Underlying Schizophrenia.Frontiers in genetics · 2018Article
- RNA-seq analysis of amygdala tissue reveals characteristic expression profiles in schizophrenia.Translational psychiatry · 2017Article
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4 authors.
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Abstract
The protein-protein interaction (PPI) networks are dynamically organized as modules, and are typically described by hub dichotomy: 'party' hubs act as intramodule hubs and are coexpressed with their partners, yet 'date' hubs act as coordinators among modules and are incoherently expressed with their partners. However, there remains skepticism about the existence of hub dichotomy. Since different algorithms and data sets were used in previous studies to test the model of hub classification, the conclusions may be largely influenced by the potential inherent biases. In this study, we evaluated two data sets of yeast interactome, and systematically investigated the behavior of hubs from multiple perspectives including co-expression patterns, topological roles and functional classifications. Our results revealed consistency between the two data sets, confirming the presence of hub dichotomy. Furthermore, we analyzed a human interactome data set, and demonstrated that the modular architecture of the PPI networks was more complicated than hub dichotomy.
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