ArticleJournal of neuroscience methods2013
Photoacoustic and optical coherence tomography of epilepsy with high temporal and spatial resolution and dual optical contrasts.
Article in Journal of neuroscience methods, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- Optoacoustic brain imaging: A systematic review and field mapping.Photoacoustics · 2026Article
- Neurophotonic methods in approach to in vivo animal epileptic models: Advantages and limitations.Epilepsia · 2024Review
- Multiscale photoacoustic tomography of neural activities with GCaMP calcium indicators.Journal of biomedical optics · 2022Article
- Photoacoustic imaging as a highly efficient and precise imaging strategy for the evaluation of brain diseases.Quantitative imaging in medicine and surgery · 2021Review
- Resolution-matched reflection mode photoacoustic microscopy and optical coherence tomography dual modality system.Photoacoustics · 2020Article
- Focal transcranial magnetic stimulation in awake rats: Enhanced glucose uptake in deep cortical layers.Journal of neuroscience methods · 2020Article
- Transcranial photoacoustic imaging of NMDA-evoked focal circuit dynamics in the rat hippocampus.Journal of neural engineering · 2020Article
- Biosensors for Epilepsy Management: State-of-Art and Future Aspects.Sensors (Basel, Switzerland) · 2019Review
- FirstTherapeutic advances in neurological disorders · 2019Article
- Isolated Murine Brain Model for Large-Scale Optoacoustic Calcium Imaging.Frontiers in neuroscience · 2019Article
- Review of Photoacoustic Imaging for Imaging-Guided Spinal Surgery.Neurospine · 2018Article
- Photoacoustic imaging of voltage responses beyond the optical diffusion limit.Scientific reports · 2017Article
- OCT intensity and phase fluctuations correlated with activity-dependent neuronal calcium dynamics in theBiomedical optics express · 2017Article
- Correlation between volumetric oxygenation responses and electrophysiology identifies deep thalamocortical activity during epileptic seizures.Neurophotonics · 2017Article
- Brain Vascular Imaging Techniques.International journal of molecular sciences · 2016Review
- A practical guide to photoacoustic tomography in the life sciences.Nature methods · 2016Review
- Multiscale Functional and Molecular Photoacoustic Tomography.Ultrasonic imaging · 2016Review
- Modeling of Cerebral Oxygen Transport Based on In vivo Microscopic Imaging of Microvascular Network Structure, Blood Flow, and Oxygenation.Frontiers in computational neuroscience · 2016Review
- High-resolution in vivo optical imaging of stroke injury and repair.Brain research · 2015Review
- Localization of cortical tissue optical changes during seizure activity in vivo with optical coherence tomography.Biomedical optics express · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Epilepsy mapping with high spatial and temporal resolution has great significance for both fundamental research on epileptic neurons and the clinical management of epilepsy. In this communication, we demonstrate for the first time in vivo epilepsy mapping with high spatial and temporal resolution and dual optical contrasts in an animal model. Through the variations of a depthresolved optical coherence tomography signal with optical scattering contrast, we observed that epileptic neuron activities modulated the optical refractive index of epileptic neurons and their surrounding tissue. Simultaneously, through neurovasculature coupling mechanisms and optical absorption contrast, we used photoacoustic signals to document the hemodynamic changes of the microvasculature surrounding the epileptic neurons. The epilepsy mapping results were confirmed by a simultaneously recorded electroencephalogram signal during epileptic seizure. Our new epilepsy mapping tool, with high temporal and spatial resolution and dual optical contrasts, may find many applications, such as drug development and epilepsy surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.