ReviewJournal of proteomics2013
Innovations in proteomic profiling of cancers: alternative splice variants as a new class of cancer biomarker candidates and bridging of proteomics with structural biology.
Review in Journal of proteomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- An interactive network of alternative splicing events with prognostic value in geriatric lung adenocarcinoma via the regulation of splicing factors.Bioscience reports · 2020Article
- Prognostic value and potential function of splicing events in prostate adenocarcinoma.International journal of oncology · 2018Article
- Annotation of Alternatively Spliced Proteins and Transcripts with Protein-Folding Algorithms and Isoform-Level Functional Networks.Methods in molecular biology (Clifton, N.J.) · 2017Article
- A proteogenomic approach to understand splice isoform functions through sequence and expression-based computational modeling.Briefings in bioinformatics · 2016Article
- A Network of Splice Isoforms for the Mouse.Scientific reports · 2016Article
- Functional Networks of Highest-Connected Splice Isoforms: From The Chromosome 17 Human Proteome Project.Journal of proteome research · 2015Article
- Expression profile of ZFX isoform3/variant 5 in gastric cancer tissues and its association with tumor size.Iranian journal of basic medical sciences · 2014Article
- The emerging era of genomic data integration for analyzing splice isoform function.Trends in genetics : TIG · 2014Review
- A new class of protein cancer biomarker candidates: differentially expressed splice variants of ERBB2 (HER2/neu) and ERBB1 (EGFR) in breast cancer cell lines.Journal of proteomics · 2014Review
- Plasma proteomics, the Human Proteome Project, and cancer-associated alternative splice variant proteins.Biochimica et biophysica acta · 2014Article
- The strategy, organization, and progress of the HUPO Human Proteome Project.Journal of proteomics · 2014Article
- Deep sequencing reveals new aspects of progesterone receptor signaling in breast cancer cells.PloS one · 2014Article
- Systematically differentiating functions for alternatively spliced isoforms through integrating RNA-seq data.PLoS computational biology · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Alternative splicing allows a single gene to generate multiple RNA transcripts which can be translated into functionally diverse protein isoforms. Current knowledge of splicing is derived mainly from RNA transcripts, with very little known about the expression level, 3D structures, and functional differences of the proteins. Splicing is a remarkable phenomenon of molecular and biological evolution. Studies which simply report up-regulation or down-regulation of protein or mRNA expression are confounded by the effects of mixtures of these isoforms. Besides understanding the net biological effects of the mixtures, we may be able to develop biomarker tests based on the observable differential expression of particular splice variants or combinations of splice variants in specific disease states. Here we review our work on differential expression of splice variant proteins in cancers and the feasibility of integrating proteomic analysis with structure-based conformational predictions of the differences between such isoforms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.