Evidence map›Paper›PMID 23602935›Full record

ReviewCellular signalling2013

Signaling pathways that control mRNA turnover.

Roopa Thapar, Andria P Denmon

Open access · greenAbstract readReview
In one paragraph

Review in Cellular signalling, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Control of RNA degradation in cell fate decision.Frontiers in cell and developmental biology · 2023
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. [Effect of histone acetylation/deacetylation imbalances on key gene of planar cell polarity pathway].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. MicroRNA-570-3p regulates HuR and cytokine expression in airway epithelial cells.American journal of clinical and experimental immunology · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Roopa ThaparHauptman-Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, NY 14203, USA. rthapar@hwi.buffalo.edu
Andria P Denmon
Hauptman-Woodward Medical Research Institute · USRice University · US

Funding

HOUSTON AREA MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008280 · NIGMS · RICE UNIVERSITY · PI WENSEL, THEODORE G · 1988 to 2023
$8.0M
Phosphorylation dependent recognition of a histone mRNA hairpin by SLBPR01GM076660 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MARZLUFF, WILLIAM F. · 2006 to 2009
$1.1M
NIGMS NIH HHS 1R01-GM076660NIGMS NIH HHS 2T32 GM008280NIGMS NIH HHS R01 GM076660NIGMS NIH HHS T32 GM008280
6 · The paper itself

Abstract

Cells regulate their genomes mainly at the level of transcription and at the level of mRNA decay. While regulation at the level of transcription is clearly important, the regulation of mRNA turnover by signaling networks is essential for a rapid response to external stimuli. Signaling pathways result in posttranslational modification of RNA binding proteins by phosphorylation, ubiquitination, methylation, acetylation etc. These modifications are important for rapid remodeling of dynamic ribonucleoprotein complexes and triggering mRNA decay. Understanding how these posttranslational modifications alter gene expression is therefore a fundamental question in biology. In this review we highlight recent findings on how signaling pathways and cell cycle checkpoints involving phosphorylation, ubiquitination, and arginine methylation affect mRNA turnover.

Indexed as

Signal Transductionbeta CateninExtracellular Signal-Regulated MAP KinasesHumansJNK Mitogen-Activated Protein Kinasesp38 Mitogen-Activated Protein KinasesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRNA, MessengerUbiquitinWnt Proteinsbeta CateninExtracellular Signal-Regulated MAP KinasesJNK Mitogen-Activated Protein Kinasesp38 Mitogen-Activated Protein KinasesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRNA, MessengerUbiquitinWnt Proteins

Identifiers

PMID23602935
PMCPMC3703460
OpenAlexW1973849368

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.