ReviewReproductive toxicology (Elmsford, N.Y.)2014
What is in our environment that effects puberty?
Review in Reproductive toxicology (Elmsford, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The genetic architecture of age at menarche and its causal effects on other traits.Journal of human genetics · 2024Pooled it
- DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study.Clinical epigenetics · 2023Pooled it
- Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review.European journal of endocrinology · 2021Pooled it
- Differential testicular toxicity of deoxynivalenol: insights from juvenile and adult mice.Mycotoxin research · 2026Article
- Impact of conflict-induced stress on the length of craniofacial growth.Scientific reports · 2025Article
- Internal Exposure to BTEX in Tropical Children: Does Exposure Speed Up Pubertal Development?Antioxidants (Basel, Switzerland) · 2025Article
- Precocious puberty in a rural Guatemalan boy: Unraveling the role of malnutrition and psychosocial stress.Oxford medical case reports · 2025Article
- The hippo pathway: a molecular bridge between environmental cues and pace of life.BMC ecology and evolution · 2025Review
- Differences in nutritional intake and physique according to dietary behaviors in middle school male athletes.Journal of exercise rehabilitation · 2025Article
- Combined Neurotoxic Effects of Commercial Formulations of Pyrethroid (Deltamethrin) and Neonicotinoid (Imidacloprid) Pesticides on Adult Zebrafish (Life (Basel, Switzerland) · 2025Article
- Identification of Environmental Compounds That May Trigger Early Female Puberty by Activating Human GnRHR and KISS1R.Endocrinology · 2024Article
- Association between BMI and age at menarche or spermarche among both sexes: Findings from six successive national surveys in China.Journal of global health · 2024Article
- Exposure to air pollution and precocious puberty: a systematic review.Ewha medical journal · 2024Review
- Family environmental antecedents of pubertal timing in girls and boys: A review and open questions.Hormones and behavior · 2022Review
- Impact of sleep patterns upon female neuroendocrinology and reproductive outcomes: a comprehensive review.Reproductive biology and endocrinology : RB&E · 2022Review
- Exposures during the prepuberty period and future offspring's health: evidence from human cohort studies†.Biology of reproduction · 2021Review
- Article
- Early menarche and its consequence in Korean female: reducing fructose intake could be one solution.Clinical and experimental pediatrics · 2021Article
- Machine learning identifies girls with central precocious puberty based on multisource data.JAMIA open · 2020Article
- Body mass index growth trajectories, early pubertal maturation, and short stature.Pediatric research · 2020Article
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Authors and funding
2 authors.
Funding
Abstract
Recent studies indicate that the onset of puberty is occurring at increasingly younger ages. Many etiologies have been hypothesized to be involved, but environmental exposures are among the most worrisome. Multiple organizations have endorsed the need to study and provide clinical awareness regarding the effect of a child's environment on pubertal timing. This review article summarizes the current understanding of the major environmental influences on pubertal timing, focusing on factors for which the most scientific evidence exists. The research reviewed addresses intrinsic factors unique to each individual, naturally occurring endocrine disruptors and chemical endocrine disruptors. In each category, evidence was found for and against the involvement of specific environmental factors on pubertal timing. Ultimately, an individual's environment is likely comprised of many aspects that collectively contribute to the timing of puberty. The need for research aimed at elucidating the effects of numerous specific yet disparate forms of exposures is emphasized.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.