ReviewTrends in neurosciences2013
How to erase memory traces of pain and fear.
Review in Trends in neurosciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06968871 (Effects of the Ameliorated Pap Test on Cervical Cancer Screening Participation), which is not on this map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of the Ameliorated Pap Test on Cervical Cancer Screening Participation: a Multicenter Randomized Controlled Trial
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comorbidities of bladder pain syndrome in the context of the HITOP distress category: a systematic review and meta-analysis.International urogynecology journal · 2022Pooled it
- Trial
- Review
- Auditory cortical neurons are recruited to encode fear signals and anxiety by neuroligin-3-mediated synapse formation.Translational psychiatry · 2025Article
- Genetic and Environmental Influences on Anxiety Disorders: A Systematic Review of Their Onset and Development.Cureus · 2025Review
- Homeostasis and dyshomeostasis in language and violent acting out. A dialogue between neuroscience and psychoanalysis.American journal of psychoanalysis · 2025Article
- Associative memory cells of encoding fear signals and anxiety are recruited by neuroligin-3-mediated synapse formation.Communications biology · 2024Article
- Solanesol alleviates CFA-induced chronic inflammatory pain via inhibition of proinflammatory cytokines in spinal glial cells.Heliyon · 2024Article
- A new psychotherapy that may treat PTSD in one session.Frontiers in psychiatry · 2024Article
- Nociceptor activity induces nonionotropic NMDA receptor signaling to enable spinal reconsolidation and reverse pathological pain.Science advances · 2023Article
- Prefrontal engrams of long-term fear memory perpetuate pain perception.Nature neuroscience · 2023Article
- GABAergic CaMKIIα+ Amygdala Output Attenuates Pain and Modulates Emotional-Motivational Behavior via Parabrachial Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Perceived psychosocial stressors and coping resources in chronic low back pain patients as classified by the avoidance-endurance model.Frontiers in rehabilitation sciences · 2022Article
- Antinociceptive effects of lead acetate in sciatic nerve chronic constriction injury model of peripheral neuropathy in male Wistar rats.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Bridging the Translational Divide in Pain Research: Biological, Psychological and Social Considerations.Frontiers in pharmacology · 2021Review
- The µ-opioid system in midline thalamic nuclei modulates defence strategies towards a conditioned fear stimulus in male mice.Journal of psychopharmacology (Oxford, England) · 2020Article
- Eye Movements in Response to Pain-Related Feelings in the Presence of Low and High Cognitive Loads.Behavioral sciences (Basel, Switzerland) · 2020Article
- The translatability of pain across species.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Sex differences in fear extinction.Neuroscience and biobehavioral reviews · 2019Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Pain and fear are both aversive experiences that strongly impact on behaviour and well being. They are considered protective when they lead to meaningful, adaptive behaviour such as the avoidance of situations that are potentially dangerous to the integrity of tissue (pain) or the individual (fear). Pain and fear may, however, become maladaptive if expressed under inappropriate conditions or at excessive intensities for extended durations. Currently emerging concepts of maladaptive pain and fear suggest that basic neuronal mechanisms of memory formation are relevant for the development of pathological forms of pain and fear. Thus, the processes of erasing memory traces of pain and fear may constitute promising targets for future therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.