ReviewDiabetes, obesity & metabolism2013
A review of artificial pancreas technologies with an emphasis on bi-hormonal therapy.
Review in Diabetes, obesity & metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Automated Insulin Delivery Systems in Children and Adolescents With Type 1 Diabetes: A Systematic Review and Meta-analysis of Outpatient Randomized Controlled Trials.Diabetes care · 2023Pooled it
- Dual-hormone artificial pancreas for glucose control in type 1 diabetes: A meta-analysis.Diabetes, obesity & metabolism · 2022Pooled it
- Advancements of Glucose Monitoring Biosensor: Current State, Generations of Technological Progress and Innovation Dynamics.Current pharmaceutical biotechnology · 2025Review
- Vasodilatory effects of glucagon: A possible new approach to enhanced subcutaneous insulin absorption in artificial pancreas devices.Frontiers in bioengineering and biotechnology · 2022Article
- Closed-Loop Insulin Delivery Systems: Past, Present, and Future Directions.Frontiers in endocrinology · 2022 · on this mapReview
- Design of dual hormone blood glucose therapy and comparison with single hormone using MPC algorithm.IET systems biology · 2020Article
- Blood glucose regulation and control of insulin and glucagon infusion using single model predictive control for type 1 diabetes mellitus.IET systems biology · 2020Article
- Realizing a Closed-Loop (Artificial Pancreas) System for the Treatment of Type 1 Diabetes.Endocrine reviews · 2019Review
- Artificial Pancreas Systems and Physical Activity in Patients with Type 1 Diabetes: Challenges, Adopted Approaches, and Future Perspectives.Journal of diabetes science and technology · 2019Review
- Technology in the management of type 1 diabetes mellitus - current status and future prospects.Nature reviews. Endocrinology · 2018Review
- Current status and issues of the artificial pancreas: abridged English translation of a special issue in Japanese.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2018Review
- Insulin delivery and nocturnal glucose control in children and adolescents with type 1 diabetes.Expert opinion on drug delivery · 2017Review
- Data Based Prediction of Blood Glucose Concentrations Using Evolutionary Methods.Journal of medical systems · 2017Article
- A Review of Safety and Design Requirements of the Artificial Pancreas.Annals of biomedical engineering · 2016Review
- Coming of age: the artificial pancreas for type 1 diabetes.Diabetologia · 2016Review
- Reducing Glucose Variability Due to Meals and Postprandial Exercise in T1DM Using Switched LPV Control: In Silico Studies.Journal of diabetes science and technology · 2016Article
- Immune interventions to preserve β cell function in type 1 diabetes.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2016Review
- A Review of Emerging Technologies for the Management of Diabetes Mellitus.IEEE transactions on bio-medical engineering · 2015Review
- Artificial Pancreas Project at Cambridge 2013.Diabetic medicine : a journal of the British Diabetic Association · 2015Review
- T1DM in 2014: Progress towards a bionic pancreas.Nature reviews. Endocrinology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Since the discovery of insulin, great progress has been made to improve the accuracy and safety of automated insulin delivery systems to help patients with type 1 diabetes achieve their treatment goals without causing hypoglycaemia. In recent years, bioengineering technology has greatly advanced diabetes management, with the development of blood glucose meters, continuous glucose monitors, insulin pumps and control systems for automatic delivery of one or more hormones. New insulin analogues have improved subcutaneous absorption characteristics, but do not completely eliminate the risk of hypoglycaemia. Insulin effect is counteracted by glucagon in non-diabetic individuals, while glucagon secretion in those with type 1 diabetes is impaired. The use of glucagon in the artificial pancreas is therefore a logical and feasible option for preventing and treating hypoglycaemia. However, commercially available glucagon is not stable in aqueous solution for long periods, forming potentially cytotoxic fibrils that aggregate quickly. Therefore, a more stable formulation of glucagon is needed for long-term use and storage in a bi-hormonal pump. In addition, a model of glucagon action in type 1 diabetes is lacking, further limiting the inclusion of glucagon into systems employing model-assisted control. As a result, although several investigators have been working to help develop bi-hormonal systems for patients with type 1 diabetes, most continue to utilize single hormone systems employing only insulin. This article seeks to focus on the attributes of glucagon and its use in bi-hormonal systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.