ArticleTrends in parasitology2013
The iron link between malaria and invasive non-typhoid Salmonella infections.
Article in Trends in parasitology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07416461 (Effectiveness of Malaria Vaccines in Reducing the Risk of Invasive Non-Typhoidal Salmonella Disease), which is not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Malaria Vaccines in Reducing the Risk of Invasive Non-Typhoidal Salmonella Disease (VINS)
Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- The Gut-Iron-Immune Axis in Severe Anaemia and Bacteraemia.Nutrients · 2026Review
- Article
- The genomic and epidemiological virulence patterns of Salmonella enterica serovars in the United States.PloS one · 2023Article
- DMT1 Protects Macrophages fromInternational journal of molecular sciences · 2022Article
- Events associated with susceptibility to invasive Salmonella enterica serovar Typhi in BALB/c mice previously infected with Plasmodium berghei ANKA.Scientific reports · 2021Article
- Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen.Cell reports · 2021Article
- AlteredFrontiers in immunology · 2021Article
- Dissemination of non-typhoidal Salmonella during Plasmodium chabaudi infection affects anti-malarial immunity.Parasitology research · 2019Article
- Invasive non-typhoidal Salmonella in sickle cell disease in Africa: is increased gut permeability the missing link?Journal of translational medicine · 2018Article
- The Impact of Dietary Transition Metals on Host-Bacterial Interactions.Cell host & microbe · 2018Review
- Role of Activins in Hepcidin Regulation during Malaria.Infection and immunity · 2017Article
- Child pneumonia - focus on the Western Pacific Region.Paediatric respiratory reviews · 2017Review
- Characterization of the Invasive, Multidrug Resistant Non-typhoidal Salmonella Strain D23580 in a Murine Model of Infection.PLoS neglected tropical diseases · 2015Article
- Infection-related hemolysis and susceptibility to Gram-negative bacterial co-infection.Frontiers in microbiology · 2015Review
- Parasite virulence, co-infections and cytokine balance in malaria.Pathogens and global health · 2014Review
- Epidemic increase in Salmonella bloodstream infection in children, Bwamanda, the Democratic Republic of Congo.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
- Malarial pathocoenosis: beneficial and deleterious interactions between malaria and other human diseases.Frontiers in physiology · 2014Review
- Iron, anemia and hepcidin in malaria.Frontiers in pharmacology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Epidemiological studies have demonstrated an association between malaria and invasive non-typhoid Salmonella (NTS) infections, especially in children. We explore the role of iron as a possible cofactor in this association. Malarial disease, among others, is associated with enhanced erythrophagocytosis and inflammation, which increases the iron content of macrophages and thereby also the survival of Salmonella spp. within macrophages. Whether iron supplementation programs augment the risk of invasive NTS infections in malaria-endemic regions is an important global health issue that still needs to be determined.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.